About: Polycationic graft copolymers as carriers for oligonucleotide delivery. Complexes of oligonucleotides with polycationic graft copolymers.

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About: Polycationic graft copolymers as carriers for oligonucleotide delivery. Complexes of oligonucleotides with polycationic graft copolymers. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ionic complexes of oligonucleotides and model oligophosphates with high molecular poly(L-lysine) molecules (M w = 134 000) grafted with short poly[N-(2-hydroxypropyl)- methacrylamide] chains (M w = 7000) were studied as systems suitable for gene therapy applications. Poly(L-lysine) and poly(trimethyl-ammonioethyl methacrylate chloride) homopolycations were used for comparison. PEC parameters were determined by static and dynamic light scattering methods. PECs prepared with an excess of oligophosphates were found to be stable in physiological salt conditions and in the Bovine Serum Albumin solutions. Ionic complexes of oligonucleotides and model oligophosphates with high molecular poly(L-lysine) molecules (M w = 134 000) grafted with short poly[N-(2-hydroxypropyl)- methacrylamide] chains (M w = 7000) were studied as systems suitable for gene therapy applications. Poly(L-lysine) and poly(trimethyl-ammonioethyl methacrylate chloride) homopolycations were used for comparison. PEC parameters were determined by static and dynamic light scattering methods. PECs prepared with an excess of oligophosphates were found to be stable in physiological salt conditions and in the Bovine Serum Albumin solutions. (en)
Title	Polycationic graft copolymers as carriers for oligonucleotide delivery. Complexes of oligonucleotides with polycationic graft copolymers. Polycationic graft copolymers as carriers for oligonucleotide delivery. Complexes of oligonucleotides with polycationic graft copolymers. (en)
skos:prefLabel	Polycationic graft copolymers as carriers for oligonucleotide delivery. Complexes of oligonucleotides with polycationic graft copolymers. Polycationic graft copolymers as carriers for oligonucleotide delivery. Complexes of oligonucleotides with polycationic graft copolymers. (en)
skos:notation	RIV/61389013:_____/01:55010258!RIV/2003/AV0/A55003/N
http://linked.open.../vavai/riv/strany	3096;3102
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV307/96/K226), P(KSK2055603), P(ME 362), Z(AV0Z4050913)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Šubr, Vladimír Reschel, Tomáš Koňák, Čestmír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	691616
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/01:55010258
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drug delivery; oligonuclotides; polycationic graft copolymers (en)
http://linked.open.../riv/klicoveSlovo	oligonuclotides polycationic graft copolymers drug delivery
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D7060D29BE12]
http://linked.open...i/riv/nazevZdroje	Langmuir
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20362 New macromolecular systems for targeted delivery of biological active compounds in the living organism Chemistry for application in biology and medicine
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Ulbrich, Karel Šubr, Vladimír Koňák, Čestmír Dautzenberg, H. Reschel, Tomáš Zintchenko, A.
http://linked.open...n/vavai/riv/zamer	Cílená syntéza a studium chemických, fyzikálně-chemických a fyzikálních vlastností makromolekulárních a nadmolekulárních látek a soustav pro vyspělé technologie
issn	0743-7463
number of pages	7 (xsd:int)

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