About: Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy.     Goto   Sponge   NotDistinct   Permalink

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  • RNase A unimer was conjugated with two N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, forming classic and starconjugates. Their antitumor effects were tested both in vitro and in vivo. Unlike the wild bovine pancreatic ribonuclease (RNase A), both polymer conjugates injected intraperitoneally or intravenously displayed a potent antitumor activity in nude mice bearing human melanoma. At the same time, their cytotoxic activity tested on various tumor cell lines was very low.
  • RNase A unimer was conjugated with two N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, forming classic and starconjugates. Their antitumor effects were tested both in vitro and in vivo. Unlike the wild bovine pancreatic ribonuclease (RNase A), both polymer conjugates injected intraperitoneally or intravenously displayed a potent antitumor activity in nude mice bearing human melanoma. At the same time, their cytotoxic activity tested on various tumor cell lines was very low. (en)
Title
  • Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy.
  • Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy. (en)
skos:prefLabel
  • Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy.
  • Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy. (en)
skos:notation
  • RIV/61389013:_____/01:55010081!RIV/2003/AV0/A55003/N
http://linked.open.../vavai/riv/strany
  • No.6132
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GV307/96/K226), P(KSK4055109), Z(AV0Z4050913)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 691633
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/01:55010081
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • RNase A; polymer conjugates; drug delivery (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [6E7270D3004A]
http://linked.open...v/mistoKonaniAkce
  • San Diego [US]
http://linked.open...i/riv/mistoVydani
  • San Diego
http://linked.open...i/riv/nazevZdroje
  • Proceedings.
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Poučková, P.
  • Strohalm, Jiří
  • Ulbrich, Karel
  • Zadinová, M.
  • Plocová, Daniela
  • Souček, J.
  • Hloušková, D.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Controlled Release Society
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