About: RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer

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About: RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Theoretical modeling is a powerful tool to predict radiation damage of biomolecules such as DNA, proteins and more complex biological targets. In this paper, we present damage distributions along a DNA oligomer irradiated by 10 keV electrons, 1, 2, 5, 10 and 20 MeV protons and alpha particles predicted by the simulation tool RADAMOL. The scavengeable damage of base and deoxyribose moieties due to radical attack is more important in the studied system than unscavengeable ionizations of the DNA target and surrounding bound water layer. Radiation quality does not modify distribution of primary damages along the DNA, but changes overall damage yields. For the first time, electron and hole migration along the DNA macromolecule has been taken into account in the simulation procedure. The effect of these processes on distribution of DNA damages is demonstrated. Theoretical modeling is a powerful tool to predict radiation damage of biomolecules such as DNA, proteins and more complex biological targets. In this paper, we present damage distributions along a DNA oligomer irradiated by 10 keV electrons, 1, 2, 5, 10 and 20 MeV protons and alpha particles predicted by the simulation tool RADAMOL. The scavengeable damage of base and deoxyribose moieties due to radical attack is more important in the studied system than unscavengeable ionizations of the DNA target and surrounding bound water layer. Radiation quality does not modify distribution of primary damages along the DNA, but changes overall damage yields. For the first time, electron and hole migration along the DNA macromolecule has been taken into account in the simulation procedure. The effect of these processes on distribution of DNA damages is demonstrated. (en)
Title	RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer (en)
skos:prefLabel	RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer (en)
skos:notation	RIV/61389005:_____/14:00435969!RIV15-AV0-61389005
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(LD12008)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Štěpán, Václav Davídková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav jaderné fyziky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	41173
http://linked.open...ai/riv/idVysledku	RIV/61389005:_____/14:00435969
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	radiation damage; ionizations; DNA (en)
http://linked.open.../riv/klicoveSlovo	DNA radiation damage ionizations
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[7D8224567DAB]
http://linked.open...i/riv/nazevZdroje	European Physical Journal D
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Effect of high LET radiation on specific interaction of proteins with DNA.
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Štěpán, Václav Davídková, Marie
http://linked.open...ain/vavai/riv/wos	000346058600009
issn	1434-6060
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1140/epjd/e2014-50068-8

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