About: Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Exposure of humans to mixed fields of high- and low-linear energy transfer (LET) radiation occurs in many situations. From the perspective of health risk associated with exposure to mixed fields, it is important to understand the interactions between different radiation types. In most cellular investigations on mixed beams, two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. The authors have constructed a facility where cells can be simultaneously exposed to Am-241 alpha particles and 190-kV X-rays at 37C. This study presents the technical details and the dosimetry of the setup, as well as validates the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness of the alpha particles was 2.56 for 37 and 1.90 for 10 clonogenic survival. Exposure of humans to mixed fields of high- and low-linear energy transfer (LET) radiation occurs in many situations. From the perspective of health risk associated with exposure to mixed fields, it is important to understand the interactions between different radiation types. In most cellular investigations on mixed beams, two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. The authors have constructed a facility where cells can be simultaneously exposed to Am-241 alpha particles and 190-kV X-rays at 37C. This study presents the technical details and the dosimetry of the setup, as well as validates the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness of the alpha particles was 2.56 for 37 and 1.90 for 10 clonogenic survival. (en)
Title	Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays (en)
skos:prefLabel	Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays (en)
skos:notation	RIV/61389005:_____/12:00385635!RIV13-AV0-61389005
http://linked.open...avai/predkladatel	Ústav jaderné fyziky AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z10480505)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Brabcová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav jaderné fyziky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	126770
http://linked.open...ai/riv/idVysledku	RIV/61389005:_____/12:00385635
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chinese-hamster cells; peripheral-blood lymphocytes; linear-energy-transfer (en)
http://linked.open.../riv/klicoveSlovo	peripheral-blood lymphocytes chinese-hamster cells linear-energy-transfer
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9F68BD3C20AE]
http://linked.open...i/riv/nazevZdroje	Radiation Protection Dosimetry
http://linked.open...in/vavai/riv/obor	BG
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	151
http://linked.open...iv/tvurceVysledku	Pachnerová Brabcová, Kateřina Braziewicz, J. Brehwens, K. Czub, J. Haghdoost, S. Nievaart, S. Staaf, E. Wojcik, A.
http://linked.open...ain/vavai/riv/wos	000308960900023
http://linked.open...n/vavai/riv/zamer	Jaderná fyzika a příbuzné obory v základním, aplikovaném a interdisciplinárním výzkumu
issn	0144-8420
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/rpd/ncs024
is http://linked.open...avai/riv/vysledek of	Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

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