About: Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The purpose of this study was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays. Whole blood collected from one donor was exposed to different doses of alpha particles (Am-241), X-rays and a combination of both. Micronuclei (MN) in binucleated PBL were scored as the endpoint. Moreover, the size of MN was measured. The results show that exposure of PBL to a mixed beam of high and low linear energy transfer radiation led to significantly higher than expected frequencies of MN. The measurement of MN size did not reveal any differences between the effect of alpha particles and mixed beam. In conclusion, a combined exposure of PBL to alpha particles and X-rays leads to a synergistic effect as measured by the frequency of MN. From the analysis of MN distributions, we conclude that the increase was due to an impaired repair of X-ray-induced DNA damage. The purpose of this study was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays. Whole blood collected from one donor was exposed to different doses of alpha particles (Am-241), X-rays and a combination of both. Micronuclei (MN) in binucleated PBL were scored as the endpoint. Moreover, the size of MN was measured. The results show that exposure of PBL to a mixed beam of high and low linear energy transfer radiation led to significantly higher than expected frequencies of MN. The measurement of MN size did not reveal any differences between the effect of alpha particles and mixed beam. In conclusion, a combined exposure of PBL to alpha particles and X-rays leads to a synergistic effect as measured by the frequency of MN. From the analysis of MN distributions, we conclude that the increase was due to an impaired repair of X-ray-induced DNA damage. (en)
Title	Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles (en)
skos:prefLabel	Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles (en)
skos:notation	RIV/61389005:_____/12:00380755!RIV13-AV0-61389005
http://linked.open...avai/predkladatel	Ústav jaderné fyziky AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z10480505)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Brabcová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav jaderné fyziky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	150361
http://linked.open...ai/riv/idVysledku	RIV/61389005:_____/12:00380755
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Micronuclei; LET; Combined exposure; Mixed beams; Alpha particles; X-rays (en)
http://linked.open.../riv/klicoveSlovo	Alpha particles Combined exposure LET Mixed beams Micronuclei X-rays
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[022008A2EB8C]
http://linked.open...i/riv/nazevZdroje	Radiation and Environmental Biophysics
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Pachnerová Brabcová, Kateřina Braziewicz, J. Brehwens, K. Czub, J. Haghdoost, S. Nievaart, S. Staaf, E. Wojcik, A.
http://linked.open...ain/vavai/riv/wos	000306694000006
http://linked.open...n/vavai/riv/zamer	Jaderná fyzika a příbuzné obory v základním, aplikovaném a interdisciplinárním výzkumu
issn	0301-634X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00411-012-0417-x
is http://linked.open...avai/riv/vysledek of	Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles

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