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  • Raman spectroscopy was applied to the analysis of structural changes in lyophilised sodium hyaluronate after proton and gamma irradiation (0.5, 5, 50, 100, 200 and 600 Gy). Characteristic Raman bands of the polysaccharide were sensitive to irradiation. Significant damage was observed at doses of 50 Gy or higher. The spectral changes confirmed radiation-induced loss of native solution conformation, destruction of primary structure, fragmentation, cross-linking and elimination of functional groups. Differences in the effects of proton and gamma radiation on sodium hyaluronate are discussed.
  • Raman spectroscopy was applied to the analysis of structural changes in lyophilised sodium hyaluronate after proton and gamma irradiation (0.5, 5, 50, 100, 200 and 600 Gy). Characteristic Raman bands of the polysaccharide were sensitive to irradiation. Significant damage was observed at doses of 50 Gy or higher. The spectral changes confirmed radiation-induced loss of native solution conformation, destruction of primary structure, fragmentation, cross-linking and elimination of functional groups. Differences in the effects of proton and gamma radiation on sodium hyaluronate are discussed. (en)
Title
  • Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation
  • Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation (en)
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  • Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation
  • Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation (en)
skos:notation
  • RIV/61389005:_____/11:00346760!RIV12-AV0-61389005
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  • V, Z(AV0Z10480505), Z(MSM6046137307)
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  • 3
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  • 225650
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  • RIV/61389005:_____/11:00346760
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  • sodium hyaluronate; proton irradiation; gamma irradiation; Raman spectroscopy (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [34366410C30B]
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  • Journal of Raman Spectroscopy
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  • 42
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  • Davídková, Marie
  • Alexa, P.
  • Synytsya, A.
  • Volka, K.
  • Wagner, Richard
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  • 000288544000044
http://linked.open...n/vavai/riv/zamer
issn
  • 0377-0486
number of pages
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  • 10.1002/jrs.2724
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