About: The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS).     Goto   Sponge   NotDistinct   Permalink

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  • The radionuclide 166Ho is successfully produced in LWR-15 Nuclear research reactor at the Institute of Nuclear Research in Řež. Its physical properties (.beta.-decay, the maximum .beta. energy 1,84 MeV, half-time 26,8 d) are suitable for a plentyof medical applications, e.g. skin and hepatic malignancies, rheumatoid arthritis. 166Ho-BMA are obtained by irradiating of inactive 166Ho-BMA. These are prepared by reacting ofthe aqueous solution Ho(NO3)3 . 5H20 with 2,5 M sodium borohydride (NaBH4) solution in 0,2 M NaOH. The particle size distributions is 1 to 170 .mu.m. 166Ho-PLA-MS are obtained by irradiating of inacti ve 166Ho-PLA-MS. These are prepared by reacting of the aqueous solution Ho(AcAc)3 with chloroform solution poly(1-lactic acid). The acetylacetone complex of holmium is prepared by its precipitation into the aqueous phaseafter adding of the aqueous solution HoC13. 6 H20 to the aqueous solution NH4AcAc. The in vitro stability studies are carried out by incubating BMA in 6 ml of saline (vario
  • The radionuclide 166Ho is successfully produced in LWR-15 Nuclear research reactor at the Institute of Nuclear Research in Řež. Its physical properties (.beta.-decay, the maximum .beta. energy 1,84 MeV, half-time 26,8 d) are suitable for a plentyof medical applications, e.g. skin and hepatic malignancies, rheumatoid arthritis. 166Ho-BMA are obtained by irradiating of inactive 166Ho-BMA. These are prepared by reacting ofthe aqueous solution Ho(NO3)3 . 5H20 with 2,5 M sodium borohydride (NaBH4) solution in 0,2 M NaOH. The particle size distributions is 1 to 170 .mu.m. 166Ho-PLA-MS are obtained by irradiating of inacti ve 166Ho-PLA-MS. These are prepared by reacting of the aqueous solution Ho(AcAc)3 with chloroform solution poly(1-lactic acid). The acetylacetone complex of holmium is prepared by its precipitation into the aqueous phaseafter adding of the aqueous solution HoC13. 6 H20 to the aqueous solution NH4AcAc. The in vitro stability studies are carried out by incubating BMA in 6 ml of saline (vario (en)
Title
  • The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS).
  • The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS). (en)
skos:prefLabel
  • The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS).
  • The in vitro and in vivo stability studies on neutron-activated .sub.166 Ho-boromacroaggregates (BMA) and .sub.166 Ho-Poly(l-lactic acid)microspheres (PLA-MS). (en)
skos:notation
  • RIV/61389005:_____/00:49010396!RIV/2003/AV0/A49003/N
http://linked.open.../vavai/riv/strany
  • 1013
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z1048901)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 713334
http://linked.open...ai/riv/idVysledku
  • RIV/61389005:_____/00:49010396
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  • N/A (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [6BBE7ED79A56]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Nuclear Medicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Kropáček, Martin
  • Lang, O.
  • Melichar, František
  • Kleisner, I.
  • Henková, K.
http://linked.open...n/vavai/riv/zamer
issn
  • 0340-6997
number of pages
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