About: Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Thymidine conjugates containing metallacarborane, {8-[5-(N-3-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (5) and {8-[5-(O-4-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (6) ions and several simple [3-cobalt bis(1,2-dicarbollide)]- ion (1) derivatives have been studied as potential boron carriers for BNCT. Compound 6 and some nonnucleoside derivatives of 1 were not toxic above 100 mu M. The partition coefficient for both metallacarborane bearing thymidine conjugates 5 and 6 was more than 500 times higher than that of unmodified nucleoside. The cellular uptake studies showed accumulation of compounds 6 in V79 Chinese hamster cells but not of compound 5. The low toxicity of conjugate type of 6 together with its high partition coefficient suggest that judicially designed derivatives of metallacarboranes can be considered as potential boron carriers for BNCT. Thymidine conjugates containing metallacarborane, {8-[5-(N-3-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (5) and {8-[5-(O-4-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (6) ions and several simple [3-cobalt bis(1,2-dicarbollide)]- ion (1) derivatives have been studied as potential boron carriers for BNCT. Compound 6 and some nonnucleoside derivatives of 1 were not toxic above 100 mu M. The partition coefficient for both metallacarborane bearing thymidine conjugates 5 and 6 was more than 500 times higher than that of unmodified nucleoside. The cellular uptake studies showed accumulation of compounds 6 in V79 Chinese hamster cells but not of compound 5. The low toxicity of conjugate type of 6 together with its high partition coefficient suggest that judicially designed derivatives of metallacarboranes can be considered as potential boron carriers for BNCT. (en) K novým bórovým nosičům pro bor- neutron záchytovou terapii: metallakarborany a jejich nukleosidové konjugáty. (cs)
Title	Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates (en) K novým bórovým nosičům pro bor- neutron záchytovou terapii: metallakarborany a jejich nukleosidové konjugáty (cs)
skos:prefLabel	Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates (en) K novým bórovým nosičům pro bor- neutron záchytovou terapii: metallakarborany a jejich nukleosidové konjugáty (cs)
skos:notation	RIV/61388980:_____/05:00029921!RIV06-AV0-61388980
http://linked.open.../vavai/riv/strany	4168;4175
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z40320502)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Plešek, Jaromír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav anorganické chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	546966
http://linked.open...ai/riv/idVysledku	RIV/61388980:_____/05:00029921
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	molecular structure; boron neutron capture therapy (en)
http://linked.open.../riv/klicoveSlovo	molecular structure boron neutron capture therapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[375A1FC7FCF0]
http://linked.open...i/riv/nazevZdroje	Bioorganic Medical Chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Plešek, Jaromír Lesnikowski, Z. J. Olejniczak, A. B. Gabel, D. Paradowska, E. Schinazi, R. F. Schussler, U. Seekamp, P. Studzinska, M.
http://linked.open...n/vavai/riv/zamer	Design, syntéza a charakterizace klastrů, kompozitů, komplexů a dalších sloučenin na bázi anorganických látek; mechanismy a kinetika jejich interakcí
issn	0968-0896
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

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