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rdf:type
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Description
| - Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory effects of nanoparticles and may provide a basis for designing environmentally safer nanomaterials.
- Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory effects of nanoparticles and may provide a basis for designing environmentally safer nanomaterials. (en)
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Title
| - The invertebrate immune system as a model for investigating the environmental impact of nanoparticles
- The invertebrate immune system as a model for investigating the environmental impact of nanoparticles (en)
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skos:prefLabel
| - The invertebrate immune system as a model for investigating the environmental impact of nanoparticles
- The invertebrate immune system as a model for investigating the environmental impact of nanoparticles (en)
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skos:notation
| - RIV/61388971:_____/13:00425739!RIV15-AV0-61388971
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/13:00425739
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Invertebrate; innate immunity; hemocyte (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Nanoparticles and the Immune System
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...v/pocetStranKnihy
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Procházková, Petra
- Canesi, L.
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - Academic Press, Elsevier Inc
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https://schema.org/isbn
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