About: Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture

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About: Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The flavonolignan isosilybin (1) is one of the silybin congeners contained in the silymarin complex, which is isolated from the seeds of the milk thistle (Silybum marianum). A number of recent studies have demonstrated that isosilybin is probably the most potent anticancer agent found in silymarin. It occurs as a mixture of two diastereoisomers, A and B. Lipase Novozym 435 was found to allow the preparative production of both optically pure isosilybin A and B in a diastereoisomeric purity of over 95%. A preparatory method based on the enzymatic resolution and other purification methods has been developed, enabling multigram amounts of both optically pure isosilybins A (1a) and B (1b) to be obtained The flavonolignan isosilybin (1) is one of the silybin congeners contained in the silymarin complex, which is isolated from the seeds of the milk thistle (Silybum marianum). A number of recent studies have demonstrated that isosilybin is probably the most potent anticancer agent found in silymarin. It occurs as a mixture of two diastereoisomers, A and B. Lipase Novozym 435 was found to allow the preparative production of both optically pure isosilybin A and B in a diastereoisomeric purity of over 95%. A preparatory method based on the enzymatic resolution and other purification methods has been developed, enabling multigram amounts of both optically pure isosilybins A (1a) and B (1b) to be obtained (en)
Title	Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture (en)
skos:prefLabel	Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture (en)
skos:notation	RIV/61388971:_____/13:00395424!RIV14-MSM-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP207/10/0288), P(ME10027)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Gažák, Radek Kuzma, Marek Křen, Vladimír Marhol, Petr Fuksová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	99010
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/13:00395424
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Isosilybin; Silymarin; Novozym 435 (en)
http://linked.open.../riv/klicoveSlovo	Isosilybin Novozym 435 Silymarin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F37202D8024D]
http://linked.open...i/riv/nazevZdroje	Process Biochemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedical investigation of optically pure silybin derivatives – from “soft” nutraceuticals to targeted anticancer drug. Isosilybin: Combined chemo-enzymatic approaches for preparation of optically pure stereoisomers and derivatives.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Gažák, Radek Křen, Vladimír Kuzma, Marek Marhol, Petr Fuksová, Kateřina Agarwal, R.
http://linked.open...ain/vavai/riv/wos	000316426000023
issn	1359-5113
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.procbio.2012.11.006

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