About: Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	beta-N-Acetylhexosaminidases (EC 3.2.1.52) from the CAZy glycoside hydrolase families 20 and 84 are two distinct enzyme groups with similar reactivity and different physiological functions, thus selective inhibition of these enzymes is of crucial importance. Here, we report on the lipase-catalyzed synthesis of a set of novel monomeric and dimeric C-6-acylated derivatives of NAG-thiazoline, which is a typical competitive inhibitor of both these enzyme classes. The prepared compounds were tested as potential inhibitors of a fungal GH20 beta-N-acetylhexosaminidase from Talaromyces flavus, however, the results of the inhibition tests were quite ambiguous. The observed inhibition was generally weak with some features of competitive inhibition (increase of K-M), but the overall pattern appeared indecisive beta-N-Acetylhexosaminidases (EC 3.2.1.52) from the CAZy glycoside hydrolase families 20 and 84 are two distinct enzyme groups with similar reactivity and different physiological functions, thus selective inhibition of these enzymes is of crucial importance. Here, we report on the lipase-catalyzed synthesis of a set of novel monomeric and dimeric C-6-acylated derivatives of NAG-thiazoline, which is a typical competitive inhibitor of both these enzyme classes. The prepared compounds were tested as potential inhibitors of a fungal GH20 beta-N-acetylhexosaminidase from Talaromyces flavus, however, the results of the inhibition tests were quite ambiguous. The observed inhibition was generally weak with some features of competitive inhibition (increase of K-M), but the overall pattern appeared indecisive (en)
Title	Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase (en)
skos:prefLabel	Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase (en)
skos:notation	RIV/61388971:_____/13:00395403!RIV14-MSM-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP207/11/0629), P(LD13042), P(OC09045), Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	MAR
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slámová, Kristýna Krejzová, Jana Vavříková, Eva Křen, Vladimír Pelantová, Helena Šimon, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	73078
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/13:00395403
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NAG-thiazoline; Lipase; Vinyl ester (en)
http://linked.open.../riv/klicoveSlovo	NAG-thiazoline Vinyl ester Lipase
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[25606F6D56AF]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Catalysis B-Enzymatic
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Thiazolinové inhibitory β-N-acetylhexosaminidas založené na nových, nepřirozených substrátech Selective enzymatic oxidations and deracemizations of natural products and biomolecules Enzymatic synthesis of multivalent glycoconjugates of natural and biologically active compounds.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	87
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Pelantová, Helena Riva, S. Slámová, Kristýna Vavříková, Eva Spiwok, V. Šimon, Petr Krejzová, Jana
http://linked.open...ain/vavai/riv/wos	000314012900019
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií
issn	1381-1177
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molcatb.2012.10.016

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software