About: Enzymatic glycosylation of multivalent scaffolds

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The design of glycoclusters, glycodendrimers, glycopolymers and other complex glycostructures that mimic the multivalent carbohydrate display on the cell surface is of immense interest for diagnosis and therapy. This review presents a detailed insight into the exciting possibilities of multiple glycosylation using enzymes, particularly glycosyltransferases (EC 2.4). A representative choice of available scaffolds for the enzyme action is practically infinite and comprises synthetic polymers, carbosilane dendrimers, multiantennary glycans or hyperbranched conjugates. The introduced glyco-patterns range from common sialyl Lewis(x) and sialyl lacto-chains to chemically functionalized carbohydrate units for detection purposes. The possibilities of in vitro enzymatic production of N- and O-glycans and other natural polymers are also discussed. In harmony with their natural tasks, glycosyltransferases may in vitro complete the imperfect glycosylation pattern of proteins, recombinantly produced in pro- and eukaryotic hosts. What is more, the required enzymatic battery may be directly co-expressed with the protein, in order to elegantly accomplish the production of eukaryotic glycans The design of glycoclusters, glycodendrimers, glycopolymers and other complex glycostructures that mimic the multivalent carbohydrate display on the cell surface is of immense interest for diagnosis and therapy. This review presents a detailed insight into the exciting possibilities of multiple glycosylation using enzymes, particularly glycosyltransferases (EC 2.4). A representative choice of available scaffolds for the enzyme action is practically infinite and comprises synthetic polymers, carbosilane dendrimers, multiantennary glycans or hyperbranched conjugates. The introduced glyco-patterns range from common sialyl Lewis(x) and sialyl lacto-chains to chemically functionalized carbohydrate units for detection purposes. The possibilities of in vitro enzymatic production of N- and O-glycans and other natural polymers are also discussed. In harmony with their natural tasks, glycosyltransferases may in vitro complete the imperfect glycosylation pattern of proteins, recombinantly produced in pro- and eukaryotic hosts. What is more, the required enzymatic battery may be directly co-expressed with the protein, in order to elegantly accomplish the production of eukaryotic glycans (en)
Title	Enzymatic glycosylation of multivalent scaffolds Enzymatic glycosylation of multivalent scaffolds (en)
skos:prefLabel	Enzymatic glycosylation of multivalent scaffolds Enzymatic glycosylation of multivalent scaffolds (en)
skos:notation	RIV/61388971:_____/13:00395327!RIV14-MSM-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP207/10/0321), P(LD13042)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bojarová, Pavla Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	73076
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/13:00395327
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-ACETYLGLUCOSAMINYLTRANSFERASE-III; MUCIN TANDEM REPEAT; NEIGHBORING RESIDUE GLYCOSYLATION (en)
http://linked.open.../riv/klicoveSlovo	MUCIN TANDEM REPEAT N-ACETYLGLUCOSAMINYLTRANSFERASE-III NEIGHBORING RESIDUE GLYCOSYLATION
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[38D29E2AB503]
http://linked.open...i/riv/nazevZdroje	Chemical Society Reviews
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Enzymatic synthesis of multivalent glycoconjugates of natural and biologically active compounds. The ways to N-acetyl-mannosamine structures via mannoside metabolizing enzymes
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Bojarová, Pavla Elling, L. Křen, Vladimír Rosencrantz, R. R.
http://linked.open...ain/vavai/riv/wos	000318791200015
issn	0306-0012
number of pages	24 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c2cs35395d

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