About: Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment     Goto   Sponge   NotDistinct   Permalink

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Description
  • The importance of glycans in biological systems is highlighted by their various functions in physiological and pathological processes. Many glycan epitopes on glycoproteins and glycolipids are based on N-acetyllactosamine units (LacNAc; Gal beta 1,4GlcNAc) and often present on extended poly-LacNAc glycans ([Gal beta 1,4GlcNAc](n)). Poly-LacNAc itself has been identified as a binding motif of galectins, an important class of lectins with functions in immune response and tumorigenesis. Therefore, the synthesis of natural and modified poly-LacNAc glycans is of specific interest for binding studies with galectins as well as for studies of their possible therapeutic applications. We present the oxidation by galactose oxidase and subsequent chemical or enzymatic modification of terminal galactose and N-acetylgalactosamine residues of poly-N-acetyllactosamine (poly-LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) by galactose oxidase
  • The importance of glycans in biological systems is highlighted by their various functions in physiological and pathological processes. Many glycan epitopes on glycoproteins and glycolipids are based on N-acetyllactosamine units (LacNAc; Gal beta 1,4GlcNAc) and often present on extended poly-LacNAc glycans ([Gal beta 1,4GlcNAc](n)). Poly-LacNAc itself has been identified as a binding motif of galectins, an important class of lectins with functions in immune response and tumorigenesis. Therefore, the synthesis of natural and modified poly-LacNAc glycans is of specific interest for binding studies with galectins as well as for studies of their possible therapeutic applications. We present the oxidation by galactose oxidase and subsequent chemical or enzymatic modification of terminal galactose and N-acetylgalactosamine residues of poly-N-acetyllactosamine (poly-LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) by galactose oxidase (en)
Title
  • Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment
  • Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment (en)
skos:prefLabel
  • Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment
  • Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment (en)
skos:notation
  • RIV/61388971:_____/12:00377487!RIV13-MSM-61388971
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • P(OC09045)
http://linked.open...iv/cisloPeriodika
  • MAY 9 2012
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 126975
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/12:00377487
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • chemo-enzymatic synthesis; galactose oxidase; glycosyltransferase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [16913E86DEA4]
http://linked.open...i/riv/nazevZdroje
  • Beilstein Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Elling, L.
  • Křen, Vladimír
  • Pelantová, Helena
  • Rosencrantz, R. R.
  • Drozdová, Anna
  • Henßen, B.
  • Kupper, E. Ch.
  • Thönes, S.
http://linked.open...ain/vavai/riv/wos
  • 000303799000001
issn
  • 1860-5397
number of pages
http://bibframe.org/vocab/doi
  • 10.3762/bjoc.8.80
is http://linked.open...avai/riv/vysledek of
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