About: Novel %22soft%22 biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Herein, the synthesis and characterization of a new aliphatic biodegradable copolyester named PBS/PBDL (poly(butylene succinate-co-butylene dilinoleate)) is reported. Surfactant-free, narrowly distributed, nanosized spherical particles (RH < 60 nm) have been produced from the biodegradable material by applying a single-step nanoprecipitation protocol. Their structure was characterized in detail by employing a variety of scattering techniques and transmission electron microscopy (TEM). Combined SLS and DLS measurements suggested that the nanoparticles comprise a porous core conferring a non-compact characteristic. Their porosity enables water to be entrapped which is responsible for their pronounced stability and relatively fast degradation as followed by size exclusion chromatography (SEC). Herein, the synthesis and characterization of a new aliphatic biodegradable copolyester named PBS/PBDL (poly(butylene succinate-co-butylene dilinoleate)) is reported. Surfactant-free, narrowly distributed, nanosized spherical particles (RH < 60 nm) have been produced from the biodegradable material by applying a single-step nanoprecipitation protocol. Their structure was characterized in detail by employing a variety of scattering techniques and transmission electron microscopy (TEM). Combined SLS and DLS measurements suggested that the nanoparticles comprise a porous core conferring a non-compact characteristic. Their porosity enables water to be entrapped which is responsible for their pronounced stability and relatively fast degradation as followed by size exclusion chromatography (SEC). (en)
Title	Novel %22soft%22 biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system Novel %22soft%22 biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system (en)
skos:prefLabel	Novel %22soft%22 biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system Novel %22soft%22 biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system (en)
skos:notation	RIV/61388971:_____/12:00376067!RIV13-AV0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP208/10/1600), P(IAAX00500803), Z(AV0Z40500505), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Říhová, Blanka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	154811
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/12:00376067
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biodegradable nanoparticles; light scattering from polymer nanoparticles; drug release (en)
http://linked.open.../riv/klicoveSlovo	drug release biodegradable nanoparticles light scattering from polymer nanoparticles
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FF9EEBE80AE6]
http://linked.open...i/riv/nazevZdroje	Soft Matter
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymeric particles and nanostructured materials stabilized by surface active molecules Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Ulbrich, Karel Říhová, Blanka Štěpánek, Petr Brus, Jiří Giacomelli, F. C. Jäger, Alessandro Jäger, Eliezer Kobera, Libor Gromadzki, Daniel El Fray, M. Kozlowska, A.
http://linked.open...ain/vavai/riv/wos	000302030200008
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Microorganisms in Research and Biotechnology
issn	1744-683X
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/C2SM07247E
is http://linked.open...avai/riv/vysledek of	Novel "soft" biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

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