About: Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry     Goto   Sponge   NotDistinct   Permalink

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  • Paper describes structural changes of the bovine adenine nucleotide transporter (bAncp). bAncp is an integral membrane protein responsible for the transport of ADP and ATP across the mitochondrial membrane. bAncp can be inhibited by various poisons. We focused on the complex with carboxyatractyloside for which the high-resolution structure is known and with bongkrekic acid for which the mechanism of inhibition remains hidden. Using hydrogen/deuterium exchange coupled to mass spectrometry we showed that each inhibitor locks the carrier in a different conformation and thus offers unique view on the carrier function
  • Paper describes structural changes of the bovine adenine nucleotide transporter (bAncp). bAncp is an integral membrane protein responsible for the transport of ADP and ATP across the mitochondrial membrane. bAncp can be inhibited by various poisons. We focused on the complex with carboxyatractyloside for which the high-resolution structure is known and with bongkrekic acid for which the mechanism of inhibition remains hidden. Using hydrogen/deuterium exchange coupled to mass spectrometry we showed that each inhibitor locks the carrier in a different conformation and thus offers unique view on the carrier function (en)
Title
  • Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry
  • Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry (en)
skos:prefLabel
  • Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry
  • Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry (en)
skos:notation
  • RIV/61388971:_____/10:00354271!RIV11-AV0-61388971
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • 45
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 251848
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/10:00354271
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ADENINE-NUCLEOTIDE CARRIER; ADP ATP CARRIER; PHOSPHOLIPASE A(2) (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [C042D4410E7E]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 285
http://linked.open...iv/tvurceVysledku
  • Forest, E.
  • Man, Petr
  • Brandolin, G.
  • Clemencon, B.
  • Pelosi, L.
  • Rey, M.
  • Trezeguet, V.
http://linked.open...ain/vavai/riv/wos
  • 000283659100072
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9258
number of pages
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