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  • Paper describes mechanism of molecular activation of p47phox, one part of the NADPH oxidase complex. P47phox is a modular multidomain protein that is known to undergo process of activation via phosphorylation. Due to the modular nature and its size it is impossible to solve the structure of autoinhibited and activated form by NMR or crystallography. Therefore we used hydrogen/deuterium exchange coupled to mass spectrometry to describe the structural differences between the two forms. We show that the protein undergoes opening upon activation and described the key regions involved in the interaction in the auto-inhibited state
  • Paper describes mechanism of molecular activation of p47phox, one part of the NADPH oxidase complex. P47phox is a modular multidomain protein that is known to undergo process of activation via phosphorylation. Due to the modular nature and its size it is impossible to solve the structure of autoinhibited and activated form by NMR or crystallography. Therefore we used hydrogen/deuterium exchange coupled to mass spectrometry to describe the structural differences between the two forms. We show that the protein undergoes opening upon activation and described the key regions involved in the interaction in the auto-inhibited state (en)
Title
  • p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex
  • p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex (en)
skos:prefLabel
  • p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex
  • p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex (en)
skos:notation
  • RIV/61388971:_____/10:00354237!RIV11-AV0-61388971
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika
  • 37
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 283543
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/10:00354237
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • SRC HOMOLOGY-3 DOMAINS; PHOSPHORYLATION-INDUCED ACTIVATION; TANDEM SH3 DOMAINS (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [6D34021EA01A]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 285
http://linked.open...iv/tvurceVysledku
  • Forest, E.
  • Man, Petr
  • Fieschi, F.
  • Marcoux, J.
  • Petit-Haertlein, I.
  • Vives, C.
http://linked.open...ain/vavai/riv/wos
  • 000281594000063
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9258
number of pages
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