About: Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

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About: Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Formation of stres granules (SGs) has not yet been described in S. cerevisiae. We showed that robust heat shock induced accumulation of eIF3a/Tif32p/Rpg1p in cytoplasmic foci. They also contained eIF3b/Prt1p, eIF3c/Nip1p, eIF4G2, Pab1p, mRNA and small but not large ribosomes and eIF2a/Sui2p. Surprisingly, Dcp2p and Dhh1p P-body markers also co-localized with eIF3a, however, since formation of eIF3-accumulations required different scaffolding proteins than P-bodies, we suggest that they represent yeast specific SGs Formation of stres granules (SGs) has not yet been described in S. cerevisiae. We showed that robust heat shock induced accumulation of eIF3a/Tif32p/Rpg1p in cytoplasmic foci. They also contained eIF3b/Prt1p, eIF3c/Nip1p, eIF4G2, Pab1p, mRNA and small but not large ribosomes and eIF2a/Sui2p. Surprisingly, Dcp2p and Dhh1p P-body markers also co-localized with eIF3a, however, since formation of eIF3-accumulations required different scaffolding proteins than P-bodies, we suggest that they represent yeast specific SGs (en) Tvorba stresových granulí v kvasince Saccharomyces cerevisiae dosud nebyla popsána. Ukázali jsme, že robustní teplotní stres indukuje akumulaci eIF3a/Tif32p/Rpg1p v cytoplazmatických ohniscích. Ty také obsahují eIF3b/Prt1p, eIF3c/Nip1p, eIF4G2, Pab1p, mRNA a malou, ale ne velkou ribosomální podjednotku a faktor eIF2a/Sui2. V těchto místech se překvapivě také nachází proteiny P-bodies Dcp2 a Dhh1. Jelikož však akumulace eIF3 vyžaduje jiné strukturální proteiny než P-bodies, považujeme vznikající akumulace eIF3a za stresové granule (cs)
Title	Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae Robustní teplotní stres nezávisle na fosforylaci eIF2alfa indukuje v kvasince Saccharomyces cerevisiae tvorbu stresových granulí obsahujících eIF3 a 40S ribosomální podjednotku (cs) Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae (en)
skos:prefLabel	Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae Robustní teplotní stres nezávisle na fosforylaci eIF2alfa indukuje v kvasince Saccharomyces cerevisiae tvorbu stresových granulí obsahujících eIF3 a 40S ribosomální podjednotku (cs) Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae (en)
skos:notation	RIV/61388971:_____/09:00326270!RIV09-AV0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/02/1424), P(GA204/05/0838), P(GA204/09/1924), P(LC545), P(ME 939), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Nováková, Lenka Vašicová, Pavla Frýdlová, Ivana Vojtová, Jana Valášek, Leoš Malínská, Kateřina Malcová, Ivana Hašek, Jiří Groušl, Tomáš Janošková, Dana Janda, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	339581
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/09:00326270
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p-bodies; stress granules; yeast (en)
http://linked.open.../riv/klicoveSlovo	yeast stress granules p-bodies
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FA095D33E2FF]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Science
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional Organisation of the Cell Role of cytoskeletal interactions of the translation initiation factor eIF3 in yeast morphogenesis Role of endocytic machinery in gene expression controls http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20939 Role of eIF3a/Rpg1p in reassembly of microtubules and stress response in yeast
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	122
http://linked.open...iv/tvurceVysledku	Nováková, Lenka Valášek, Leoš Malínská, Kateřina Hašek, Jiří Groušl, Tomáš Frýdlová, Ivana Malcová-Janatová, Ivana Vašicová, Pavla Janda, Filip Janošková, Dana Vojtová, Jana Ivanov, P.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0021-9533
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

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