About: Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency. The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency. (en)
Title	Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position (en)
skos:prefLabel	Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position (en)
skos:notation	RIV/61388963:_____/14:00430390!RIV15-GA0-61388963
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP303/11/1297)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Plačková, Pavla Jansa, Petr Dračínský, Martin Hřebabecký, Hubert Nencka, Radim Mertlíková-Kaiserová, Helena Dejmek, Milan Šála, Michal Procházková, Eliška
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	49044
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/14:00430390
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antiviral; coxsackievirus B3; enteroviruses; phosphatidylinositol 4-kinase (PI4K); purines (en)
http://linked.open.../riv/klicoveSlovo	antiviral phosphatidylinositol 4-kinase (PI4K) purines coxsackievirus B3 enteroviruses
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[5BA0ABF70612]
http://linked.open...i/riv/nazevZdroje	Archiv der Pharmazie
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of antiviral and cytostatic effects of novel carbocyclic nucleoside analogs
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	347
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Dejmek, Milan Hřebabecký, Hubert Jansa, Petr Leyssen, P. Mertlíková-Kaiserová, Helena Nencka, Radim Neyts, J. Šála, Michal Procházková, Eliška Plačková, Pavla Borreda, L. M.
http://linked.open...ain/vavai/riv/wos	000338940600003
issn	0365-6233
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ardp.201300431

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