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rdf:type
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Description
| - 3-Hydroxycyclopent-1-enecarboxylic acid (HOCPCA, 1) is a potent ligand for the high-affinity GHB binding sites in the CNS. An improved synthesis of 1 together with a very efficient synthesis of [H-3]-1 is described. The radiosynthesis employs in situ generated lithium trimethoxyborotritide. Screening of 1 against different CNS targets establishes a high selectivity, and we demonstrate in vivo brain penetration. In vitro characterization of [H-3]-1 binding shows high specificity to the high-affinity GHB binding sites.
- 3-Hydroxycyclopent-1-enecarboxylic acid (HOCPCA, 1) is a potent ligand for the high-affinity GHB binding sites in the CNS. An improved synthesis of 1 together with a very efficient synthesis of [H-3]-1 is described. The radiosynthesis employs in situ generated lithium trimethoxyborotritide. Screening of 1 against different CNS targets establishes a high selectivity, and we demonstrate in vivo brain penetration. In vitro characterization of [H-3]-1 binding shows high specificity to the high-affinity GHB binding sites. (en)
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Title
| - New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity gamma-Hydroxybutyrate (GHB) Binding Sites
- New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity gamma-Hydroxybutyrate (GHB) Binding Sites (en)
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skos:prefLabel
| - New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity gamma-Hydroxybutyrate (GHB) Binding Sites
- New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity gamma-Hydroxybutyrate (GHB) Binding Sites (en)
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skos:notation
| - RIV/61388963:_____/13:00421055!RIV14-AV0-61388963
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/13:00421055
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - rat-brain; acid; oxidation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Marek, Aleš
- Bay, T.
- Bundgaard, C.
- Clausen, R. P.
- Frolund, B.
- Kehler, J.
- Pedersen, M. H. F.
- Vogensen, S. B.
- Wellendorph, P.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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