About: Structural and mechanistic principles of intramembrane proteolysis lessons from rhomboids

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Intramembrane proteases cleave membrane proteins in their transmembrane helices to regulate a wide range of biological processes. They catalyse hydrolytic reactions within the hydrophobic environment of lipid membranes where water is normally excluded. How? Do the different classes of intramembrane proteases share any mechanistic principles? In this review these questions will be discussed in view of the crystal structures of prokaryotic members of the three known catalytic types of intramembrane proteases published over the past 7years. Rhomboids, the intramembrane serine proteases that are the best understood family, will be the initial area of focus, and the principles that have arisen from a number of structural and biochemical studies will be considered. The site-2 metalloprotease and GXGD-type aspartyl protease structures will then be discussed, with parallels drawn and differences highlighted between these enzymes and the rhomboids. Despite the significant advances achieved so far, to obtain a detailed understanding of the mechanism of any intramembrane protease, high-resolution structural information on the substrateenzyme complex is required. This remains a major challenge for the field. Intramembrane proteases cleave membrane proteins in their transmembrane helices to regulate a wide range of biological processes. They catalyse hydrolytic reactions within the hydrophobic environment of lipid membranes where water is normally excluded. How? Do the different classes of intramembrane proteases share any mechanistic principles? In this review these questions will be discussed in view of the crystal structures of prokaryotic members of the three known catalytic types of intramembrane proteases published over the past 7years. Rhomboids, the intramembrane serine proteases that are the best understood family, will be the initial area of focus, and the principles that have arisen from a number of structural and biochemical studies will be considered. The site-2 metalloprotease and GXGD-type aspartyl protease structures will then be discussed, with parallels drawn and differences highlighted between these enzymes and the rhomboids. Despite the significant advances achieved so far, to obtain a detailed understanding of the mechanism of any intramembrane protease, high-resolution structural information on the substrateenzyme complex is required. This remains a major challenge for the field. (en)
Title	Structural and mechanistic principles of intramembrane proteolysis lessons from rhomboids Structural and mechanistic principles of intramembrane proteolysis lessons from rhomboids (en)
skos:prefLabel	Structural and mechanistic principles of intramembrane proteolysis lessons from rhomboids Structural and mechanistic principles of intramembrane proteolysis lessons from rhomboids (en)
skos:notation	RIV/61388963:_____/13:00392839!RIV14-MSM-61388963
http://linked.open...avai/predkladatel	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP305/11/1886), P(LK11206)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Stříšovský, Kvido
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	108331
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/13:00392839
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	crystal structure; enzymatic mechanism; intramembrane protease; presenilin; rhomboid (en)
http://linked.open.../riv/klicoveSlovo	enzymatic mechanism presenilin crystal structure intramembrane protease rhomboid
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C2C5B3D7C907]
http://linked.open...i/riv/nazevZdroje	FEBS Journal
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Intramembránové proteasy rodiny rhomboidů – specifita, mechanismus a identifikace substrátů jako klíč k jejich biologickým rolím. Intramembrane proteases of the rhomboid family in the secretory pathway of mammalian cells: substrate repertoire, specificity, biological roles and their inhibition
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	280
http://linked.open...iv/tvurceVysledku	Stříšovský, Kvido
http://linked.open...ain/vavai/riv/wos	000316913500001
issn	1742-464X
number of pages	25 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/febs.12199

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