About: Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine     Goto   Sponge   NotDistinct   Permalink

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Description
  • Lipases from Geotrichum candidum 4013 (extracellular lipase and cell-bound lipase) were immobilized by adsorption on chitosan beads. The enzyme preparations were tested in the synthesis of ester prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine in dimethylformamide with different vinyl esters (acetate, butyrate, decanoate, laurate, palmitate). The transesterification activities of these immobilized enzymes were compared with commercially available lipases (lipase from hog pancreas, Aspergillus niger, Candida antarctica, Pseudomonas fluorescens).
  • Lipases from Geotrichum candidum 4013 (extracellular lipase and cell-bound lipase) were immobilized by adsorption on chitosan beads. The enzyme preparations were tested in the synthesis of ester prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine in dimethylformamide with different vinyl esters (acetate, butyrate, decanoate, laurate, palmitate). The transesterification activities of these immobilized enzymes were compared with commercially available lipases (lipase from hog pancreas, Aspergillus niger, Candida antarctica, Pseudomonas fluorescens). (en)
Title
  • Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine
  • Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine (en)
skos:prefLabel
  • Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine
  • Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine (en)
skos:notation
  • RIV/61388963:_____/12:00384593!RIV13-AV0-61388963
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  • I
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  • 12
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  • 147164
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  • RIV/61388963:_____/12:00384593
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  • lipase; transesterification; prodrug; immobilization of enzymes (en)
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  • CH - Švýcarská konfederace
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  • [F12185DF86CF]
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  • Molecules
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  • 17
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  • Krečmerová, Marcela
  • Brabcová, Jana
  • Zarevúcka, Marie
  • Blažek, Jiří
  • Janská, Lucie
http://linked.open...ain/vavai/riv/wos
  • 000312608200009
issn
  • 1420-3049
number of pages
http://bibframe.org/vocab/doi
  • 10.3390/molecules171213813
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