About: Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase

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About: Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase Goto Sponge NotDistinct Permalink

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Description	5-Aryl-1-[2-(phosphonomethoxy)ethyl]uracils were prepared via Pd-catalyzed Suzuki-Miyaura coupling reaction of the appropriate 5-bromouracil derivative with a series of arylboronic acids followed by deprotection. These compounds were designed as potential multisubstrate inhibitors of thymidine phosphorylase based on an assumption that the potential hydrophobic effect of the aryl groups might modify the inhibitory effect towards this enzyme and may also demonstrate cytostatic activity. 5-Aryl-1-[2-(phosphonomethoxy)ethyl]uracils were prepared via Pd-catalyzed Suzuki-Miyaura coupling reaction of the appropriate 5-bromouracil derivative with a series of arylboronic acids followed by deprotection. These compounds were designed as potential multisubstrate inhibitors of thymidine phosphorylase based on an assumption that the potential hydrophobic effect of the aryl groups might modify the inhibitory effect towards this enzyme and may also demonstrate cytostatic activity. (en) 5-Aryl-1-[2-(fosfonomethoxy)ethyl]uracily byly připraveny Pd-katalyzovanou Suzuki-Miyaura reakcí příslušného 5-bromuracilového derivátu s řadou arylboronových kyselin s nasledovanou deprotekcí. Tyto látky byly navrženy jako potenciální multisubstrátové inhibitory thymidinfosforylasy na základě předpokladu, že potenciální hydrofobní efekt arylové skupiny by mohl modifikovat inhibiční effekt vůči tomuto enzymu. (cs)
Title	Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase (en) Pd-katalyzovaná Suzuki-Miyaura reakce v syntéze 5-aryl-1-[2-(fosfonomethoxy)ethyl]uracilů jako potenciálních inhibitorů thymidinfosforylasy (cs)
skos:prefLabel	Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase (en) Pd-katalyzovaná Suzuki-Miyaura reakce v syntéze 5-aryl-1-[2-(fosfonomethoxy)ethyl]uracilů jako potenciálních inhibitorů thymidinfosforylasy (cs)
skos:notation	RIV/61388963:_____/07:00081288!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany	3065;3067
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Pomeisl, Karel Holý, Antonín Pohl, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	440861
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/07:00081288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acyclic nucleoside phosphonates; thymidine phosphorylase; Suzuki coupling; pyrimidine (en)
http://linked.open.../riv/klicoveSlovo	Suzuki coupling pyrimidine acyclic nucleoside phosphonates thymidine phosphorylase
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[352F8730CB2D]
http://linked.open...i/riv/nazevZdroje	Tetrahedron Letters
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Holý, Antonín Pohl, Radek Pomeisl, Karel
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0040-4039
number of pages	3 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase Pd-catalyzed Suzuki-Miyaura coupling reaction in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase

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