About: Activity and mechanism of action of insect oostatic peptides in flesh fly

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byl analysován vztah mezi strukturou a aktivitou analogů hmyzího oostatického dekapeptidu (Aed TMOF) u mouchy Neobellieria bullata. Nejvyšší oostatickou aktivitu vykazovali N-koncový pentapeptid a tetrapeptid. Metabolismus těchto peptidů je velmi rychlý, poločas v hemolymfě a homogenátu ovarií je kratší než 1 hodina. V homogenátu ovarií a v hrubém preparátu membrán byla detekována pouze velice nízká specifická vazba těchto peptidů, a to jak v přítomnosti, tak nepřítomnosti inhibitorů proteáz (cs) The relationship between structure and activity of insect oostatic decapeptide (Aed TMOF) analogues in flesh fly was analyzed. The highest oostatic activity was exhibited by the pentapeptide and tetrapeptide analogues. A high metabolism of the tetrapeptide with a half-life in the hemolymph and ovaries less than 1h was determined. Only very low specific binding was detected in the homogenates of ovaries and in the rough membrane preparation in the presence and absence of protease inhibitors The relationship between structure and activity of insect oostatic decapeptide (Aed TMOF) analogues in flesh fly was analyzed. The highest oostatic activity was exhibited by the pentapeptide and tetrapeptide analogues. A high metabolism of the tetrapeptide with a half-life in the hemolymph and ovaries less than 1h was determined. Only very low specific binding was detected in the homogenates of ovaries and in the rough membrane preparation in the presence and absence of protease inhibitors (en)
Title	Activity and mechanism of action of insect oostatic peptides in flesh fly Activity and mechanism of action of insect oostatic peptides in flesh fly (en) Aktivita a mechanismus účinku hmyzího oostatického peptidu u mouchy Neobellieria bullata (cs)
skos:prefLabel	Activity and mechanism of action of insect oostatic peptides in flesh fly Activity and mechanism of action of insect oostatic peptides in flesh fly (en) Aktivita a mechanismus účinku hmyzího oostatického peptidu u mouchy Neobellieria bullata (cs)
skos:notation	RIV/61388963:_____/04:00102868!RIV/2005/GA0/A57005/N
http://linked.open.../vavai/riv/strany	263;273
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/02/0247), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Slaninová, Jiřina Nazarov, Elšan Tykva, Richard Hlaváček, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	553471
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00102868
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oostatic activity; binding experiments; degradation (en)
http://linked.open.../riv/klicoveSlovo	degradation binding experiments oostatic activity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BE604F172B47]
http://linked.open...i/riv/nazevZdroje	Bioorganic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	A metabolism study of natural oostatic insect peptides and their synthesized analogs to optimize biological activity
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Holík, Josef Hlaváček, Jan Slaninová, Jiřina Šimek, Petr Tykva, Richard Vlasáková, Věra Bennettová, Blanka Černý, B. Nazarov, Elšan
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0045-2068
number of pages	11 (xsd:int)

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