About: Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1,2,4-thiadiazol-3(2H)-one

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About: Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1,2,4-thiadiazol-3(2H)-one Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oxidativní cyklizací thiobiuretu byl syntetizován 5-amino-1,2,4-thiadiazol-3(2H)-on, což je síru obsahující analog cytosinu, jehož CH=CH skupina v poloze 5 a 6 pyrimidinového jádra je nahrazena divalentní sírou (-S-). Vykazuje antibakteriální aktivitu a možnou karcinogenitu indikovanou DC polarografickou metodou (cs) 5-Amino-1,2,4-thiadiazol-3(2H)-one, a sulfur-containing analogue of cytosine with the -CH=CH-group between the position 5 and 6 of the pyrimidine ring replaced by the divalent sulfur (-S-) exhibiting antibacterial activity on E.coli and a possible cancerogenicity indicated by a DC polarografic method, was synthetized by oxidative cyclization of thiobiuret 5-Amino-1,2,4-thiadiazol-3(2H)-one, a sulfur-containing analogue of cytosine with the -CH=CH-group between the position 5 and 6 of the pyrimidine ring replaced by the divalent sulfur (-S-) exhibiting antibacterial activity on E.coli and a possible cancerogenicity indicated by a DC polarografic method, was synthetized by oxidative cyclization of thiobiuret (en)
Title	Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1,2,4-thiadiazol-3(2H)-one Zlepšená syntéza, antibakteriální aktivita a potenciální karcinogenita 5-amino-1,2,4-thiadiazol-3(2H)-onu (cs) Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1,2,4-thiadiazol-3(2H)-one (en)
skos:prefLabel	Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1,2,4-thiadiazol-3(2H)-one Zlepšená syntéza, antibakteriální aktivita a potenciální karcinogenita 5-amino-1,2,4-thiadiazol-3(2H)-onu (cs) Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1,2,4-thiadiazol-3(2H)-one (en)
skos:notation	RIV/61388963:_____/04:00101962!RIV/2005/AV0/A57005/N
http://linked.open.../vavai/riv/strany	756;762
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Pískala, Alois Masojídková, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	567531
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00101962
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carcinogenicity;thiadiazole;antibacterial activity (en)
http://linked.open.../riv/klicoveSlovo	antibacterial activity carcinogenicity thiadiazole
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[FEA7428BB309]
http://linked.open...i/riv/nazevZdroje	Pharmazie
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Pačes, Václav Novotný, L. Masojídková, Milena Pískala, Alois Vachálková, A. Horváthová, K. Ovesná, Z.
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0031-7144
number of pages	7 (xsd:int)

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