About: Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byly připraveny deuterované analogy pregnenolonu a pregnenolon sulfátu s třemi atomy deuteria v poloze 19. 3beta-hydroxy[19-2H3]androst-5-en-17-on byl připraven v 14 stupních z 19-hydroxy-17-oxoandrost-5-en-3beta-yl acetátu ve výtěžku 8.9%, analogická sekvence v pregnenolonové řadě poskytla 3beta-hydroxy[19-2H3]pregn-5-en-20-on ve výtěžku 7.3%. Obsah d3-derivátu byl 93-95% podle hmotnostně spektrometrické analýzy. Odpovídající sulfáty byly připraveny přes pyridiniové soli ve výtěžcích 53 a 57% (cs) Deuterated analogs of pregnenolone and pregnenolone sulfate with three atoms of deuterium in position 19 were prepared. 3beta-hydroxy[19-2H3]androst-5-en-17-one was prepared in 14 steps from 19-hydroxy-17-oxoandrost-5-en-3beta-yl acetate in 8.9% yield, the analogous sequence in the pregnenolone series gave 3beta-hydroxy[19-2H3]pregn-5-en-20-one in 7.3% yield. The content of d3-derivative was about 93-95% according to the mass spectra analysis. Corresponding sulfates were prepared via pyridinium salts in 53 and 57% yields, respectively Deuterated analogs of pregnenolone and pregnenolone sulfate with three atoms of deuterium in position 19 were prepared. 3beta-hydroxy[19-2H3]androst-5-en-17-one was prepared in 14 steps from 19-hydroxy-17-oxoandrost-5-en-3beta-yl acetate in 8.9% yield, the analogous sequence in the pregnenolone series gave 3beta-hydroxy[19-2H3]pregn-5-en-20-one in 7.3% yield. The content of d3-derivative was about 93-95% according to the mass spectra analysis. Corresponding sulfates were prepared via pyridinium salts in 53 and 57% yields, respectively (en)
Title	Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates Synthesa [19-2H3]-analogů dehydroepiandrosteronu a pregnenolonu a jejich sulfátů (cs) Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates (en)
skos:prefLabel	Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates Synthesa [19-2H3]-analogů dehydroepiandrosteronu a pregnenolonu a jejich sulfátů (cs) Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates (en)
skos:notation	RIV/61388963:_____/04:00100807!RIV/2005/AV0/A57005/N
http://linked.open.../vavai/riv/strany	161;171
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/02/1440), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Černý, Ivan Pouzar, Vladimír Buděšínský, Miloš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	589375
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00100807
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	steroid;synthesis;deuterium (en)
http://linked.open.../riv/klicoveSlovo	deuterium steroid synthesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[76C0F95C7673]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Syntheses of neurosteroid sulfates labeled with deuterium and their monitoring in human brain tumor cells
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	69
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Pouzar, Vladimír Černý, Ivan Bičíková, M. Hill, M. Hampl, R.
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0039-128X
number of pages	11 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 116 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software