About: An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine

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About: An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byla připravena série 6-alkynyl-2,4-diaminopyrimidinů Sonogashirovou reakcí 2,4-diamino-6-chlorpyrimidinu s Pd(pph3)2Cl2 jako katalysátorem. Některé z látek měly význačný cytostatický účinek (cs) A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(pph3)2Cl2 as catalyst. The same reaction was applied to 2-amino-4,6-dichloropyrimidine. Some of the resulting alkynyl pyrimidines showed considerable cytostatic activity A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(pph3)2Cl2 as catalyst. The same reaction was applied to 2-amino-4,6-dichloropyrimidine. Some of the resulting alkynyl pyrimidines showed considerable cytostatic activity (en)
Title	An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine Výhodná syntéza mono- a bis-alkynylpyrimidinů Sonogashirovou reakcí 2,4-diamino-6-jodpyrimidinu a 2-amino-4,6-dichlorpyrimidinu (cs) An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine (en)
skos:prefLabel	An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine Výhodná syntéza mono- a bis-alkynylpyrimidinů Sonogashirovou reakcí 2,4-diamino-6-jodpyrimidinu a 2-amino-4,6-dichlorpyrimidinu (cs) An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine (en)
skos:notation	RIV/61388963:_____/04:00100782!RIV/2005/AV0/A57005/N
http://linked.open.../vavai/riv/strany	4983;4987
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IBS4055109), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	23
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Votruba, Ivan Hocková, Dana Holý, Antonín Masojídková, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	554081
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00100782
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pyrimidines;cross-coupling;Sonogashira reaction (en)
http://linked.open.../riv/klicoveSlovo	Sonogashira reaction cross-coupling pyrimidines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[66C67EDF5D9A]
http://linked.open...i/riv/nazevZdroje	Tetrahedron
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Acyclic nucleoside phosponates with antineoplastic activity
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Holý, Antonín Hocková, Dana Votruba, Ivan Masojídková, Milena
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0040-4020
number of pages	5 (xsd:int)

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