About: New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	New linear cationic surfactants – 2-(alkyldimethylammonio)ethylgluconamide bromides, denoted as CnGAB, n = 10, 12, 14 and 16 – were synthesized from natural resources and characterized with respect to their potential as gene-delivery agents in gene therapy applications. Interactions with plasmid DNA and with model membranes were studied both experimentally and theoretically. The compounds with n = 12, 14 and 16 show exponentially increasing ability to fully condense DNA. C16GAB condenses DNA at 1:1 surfactant to nucleotide molar ratio. Furthermore, CnGABs interact with model membrane, slightly lowering the temperature of the main phase transition Tm of the DPPC bilayer. C10GAB is found to interact only at the membrane surface. C16GAB reduces Tm less than C12GAB and C14GAB, and forms domains in the bilayer at the surfactant/DPPC molar ratio of 0.1 and higher. The results suggest that C16GAB can be a promising candidate for building gene-delivery carrier systems. New linear cationic surfactants – 2-(alkyldimethylammonio)ethylgluconamide bromides, denoted as CnGAB, n = 10, 12, 14 and 16 – were synthesized from natural resources and characterized with respect to their potential as gene-delivery agents in gene therapy applications. Interactions with plasmid DNA and with model membranes were studied both experimentally and theoretically. The compounds with n = 12, 14 and 16 show exponentially increasing ability to fully condense DNA. C16GAB condenses DNA at 1:1 surfactant to nucleotide molar ratio. Furthermore, CnGABs interact with model membrane, slightly lowering the temperature of the main phase transition Tm of the DPPC bilayer. C10GAB is found to interact only at the membrane surface. C16GAB reduces Tm less than C12GAB and C14GAB, and forms domains in the bilayer at the surfactant/DPPC molar ratio of 0.1 and higher. The results suggest that C16GAB can be a promising candidate for building gene-delivery carrier systems. (en)
Title	New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes (en)
skos:prefLabel	New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes (en)
skos:notation	RIV/61388955:_____/13:00393961!RIV14-GA0-61388955
http://linked.open...avai/predkladatel	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GBP208/12/G016)
http://linked.open...iv/cisloPeriodika	OCT-NOV
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hof, Martin Kral, Teresa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	91584
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/13:00393961
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Glucose-derived surfactant; Soft surfactant; Cationic surfactant (en)
http://linked.open.../riv/klicoveSlovo	Cationic surfactant Glucose-derived surfactant Soft surfactant
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[EA51387F7D4B]
http://linked.open...i/riv/nazevZdroje	Biophysical Chemistry
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Controlling structure and function of biomolecules at the molecular scale: theory meets experiment
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	180-181
http://linked.open...iv/tvurceVysledku	Hof, Martin Kral, Teresa Frackowiak, R. Misiak, P. Pruchnik, H. Rózycka-Roszak, B. Wilk, K. A. Wozniak, E.
http://linked.open...ain/vavai/riv/wos	000324898700006
issn	0301-4622
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bpc.2013.06.010

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