About: Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined. Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined. (en)
Title	Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water (en)
skos:prefLabel	Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water (en)
skos:notation	RIV/61388955:_____/10:00335375!RIV11-GA0-61388955
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP203/09/P502), Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pospíšil, Lubomír Sokolová, Romana Hromadová, Magdaléna Gál, Miroslav Kolivoška, Viliam Bulíčková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	296690
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/10:00335375
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	etanidazole; radiosensitizer; electron transfer; voltammetry (en)
http://linked.open.../riv/klicoveSlovo	electron transfer etanidazole voltammetry radiosensitizer
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[CBF79F49E822]
http://linked.open...i/riv/nazevZdroje	Bioelectrochemistry
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Electrochemical Study of Redox Reactions of Radiosensitizers: Drugs that Make Radiation Work Better in Destroying Cancer Cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	78
http://linked.open...iv/tvurceVysledku	Gál, Miroslav Hromadová, Magdaléna Híveš, J. Kolivoška, Viliam Pospíšil, Lubomír Sokolová, Romana Bulíčková, Jana
http://linked.open...ain/vavai/riv/wos	000277218900004
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	1567-5394
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water

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