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  • Creatine is recommended to be administered as food supplement, which should fortify its natural formation. It is supposed that human organism utilizes this compound for creatine phosphate formation, which is necessary for energy supplementation for muscular work. It was shown that the metabolic ways are more complicated than had been supposed. The changes in thiodiglycolic acid (TDGA) excretion into urine proved that application of creatine affects the metabolism of thiocompounds and two-carbon units, i.e., levels of homocysteine and glycine in blood, and of TDGA in urine. From our results, obtained in experiments with a group of 11 young men, who were supplemented by creatine for one month, it was confirmed that the dependence interrelationship among thiocompounds, vitamin B12, folates, cholesterol, and other complex is more complicated than had been supposed. For better understanding of the role of creatine in general metabolism, ...
  • Creatine is recommended to be administered as food supplement, which should fortify its natural formation. It is supposed that human organism utilizes this compound for creatine phosphate formation, which is necessary for energy supplementation for muscular work. It was shown that the metabolic ways are more complicated than had been supposed. The changes in thiodiglycolic acid (TDGA) excretion into urine proved that application of creatine affects the metabolism of thiocompounds and two-carbon units, i.e., levels of homocysteine and glycine in blood, and of TDGA in urine. From our results, obtained in experiments with a group of 11 young men, who were supplemented by creatine for one month, it was confirmed that the dependence interrelationship among thiocompounds, vitamin B12, folates, cholesterol, and other complex is more complicated than had been supposed. For better understanding of the role of creatine in general metabolism, ... (en)
  • Kreatin je doporučován jako potravinový doplněk, který by měl zesílit jeho přirozenou tvorbu. Předpokládá se, že lidský organismus používá tuto sloučeninu pro tvorbu kreatin fosfátu, který je potřebný pro zásobování energií pro svalovou práci. Bylo prokázáno, že metabolické cesty jeho tvorby a zániku jsou komplikovanější, než bylo předpokládáno. Změny vylučování kyseliny thiodiglykolové do moči (TDGA) prokázaly, že aplikace kreatinu ovlivňuje metabolismus thio-sloučenin a dvoj-uhlíkových jednotek, tj. hladinu homocysteinu a glycinu v krvi a TDGA v moči. Z našich výsledků, získaných v experimentech se skupinou 11 mladých mužů, kteří byli suplementováni kreatinem po dobu jednoho měsíce, bylo potvrzeno, že vzájemná závislost mezi thio-sloučeninami, vitaminem B12, foláty, cholesterolem a jinými komplexy je komplikovanější než bylo předpokládáno. Pro lepší porozumění role kreatinu v obecném metabolismu bylo odvozeno schéma metabolických cest vztažených ke tvorbě kreatinu a jeho užití. (cs)
Title
  • Impact of Creatine on Coordination of Urea and Citrate Cycles
  • Impact of Creatine on Coordination of Urea and Citrate Cycles (en)
  • Vliv kreatinu na koordinaci močovinového a citrátového cyklu (cs)
skos:prefLabel
  • Impact of Creatine on Coordination of Urea and Citrate Cycles
  • Impact of Creatine on Coordination of Urea and Citrate Cycles (en)
  • Vliv kreatinu na koordinaci močovinového a citrátového cyklu (cs)
skos:notation
  • RIV/61388955:_____/06:00041254!RIV07-AV0-61388955
http://linked.open.../vavai/riv/strany
  • 21;24
http://linked.open...avai/riv/aktivita
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  • P(1H-PK/42), P(NR8107), Z(AV0Z40400503)
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  • 478891
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  • RIV/61388955:_____/06:00041254
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  • Atherosclerosis; Citrate cycle; Urea cycle; Blood (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [227C0F2814E7]
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  • Kohlíková, E.
  • Navrátil, Tomáš
  • Petr, M.
  • Heyrovský, Michael
  • Pelclová, D.
  • Přistoupil, T. I.
  • Přistoupilová, K.
  • Šenholdová, Z.
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  • Univerzita Karlova v Praze. 1. lékařská fakulta. IV. interní klinika
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  • 80-239-7726-1
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