About: The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model

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About: The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Successive phosphorylation cascades mediated by mitogen-activated protein kinases (MAPKs) are known to act as switches initiating various cellular processes. In addition, models of the MAPK reaction network are displaying other nonlinear phenomena including bistability and periodic oscillations. Recently bistability has been explained as a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in the Stage 2 subsystem of the Huang-Ferrell model of the MAPK and a core bistable model has been proposed. Here we focus on a detailed stability analysis of the steady states of this minimal model. The analysis uses methods of convex analysis and stoichiometric network theory. Successive phosphorylation cascades mediated by mitogen-activated protein kinases (MAPKs) are known to act as switches initiating various cellular processes. In addition, models of the MAPK reaction network are displaying other nonlinear phenomena including bistability and periodic oscillations. Recently bistability has been explained as a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in the Stage 2 subsystem of the Huang-Ferrell model of the MAPK and a core bistable model has been proposed. Here we focus on a detailed stability analysis of the steady states of this minimal model. The analysis uses methods of convex analysis and stoichiometric network theory. (en)
Title	The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model (en)
skos:prefLabel	The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model (en)
skos:notation	RIV/60461373:22340/13:43895757!RIV14-MSM-22340___
http://linked.open...avai/predkladatel	Fakulta chemicko-inženýrská
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME10036), Z(MSM6046137306)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hadač, Otto Schreiber, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	105796
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/13:43895757
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bistability; signaling cascade model; stoichiometric network analysis (en)
http://linked.open.../riv/klicoveSlovo	signaling cascade model stoichiometric network analysis bistability
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DFB0573177E7]
http://linked.open...i/riv/nazevZdroje	Russian Journal of Physical Chemistry A
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	87
http://linked.open...iv/tvurceVysledku	Schreiber, Igor Hadač, Otto
http://linked.open...ain/vavai/riv/wos	000324296400022
http://linked.open...n/vavai/riv/zamer	Reakčně-transportní chemicko-inženýrské systémy a jejich dynamické chování, modelování a řízení chemických a biotechnologických procesů
issn	0036-0244
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1134/S0036024413130116
http://localhost/t...ganizacniJednotka	22340

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