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| rdf:type
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| Description
| - Many scientists deal with a problem of targeted delivery of drugs nowadays. Some of these substances are not very stable, so their synthesis ?in situ? is needed. Control of reaction and release of products requires complex system, using more chemical species and compartmentalization. Our particle is generally a small alginate gel droplet embedding internal compartments and other components. Liposomes play a role of the internal compartments, because permeability of their membrane could be greatly modified by temperature. Alginate beads also contain magnetite nanoparticles so heat can be generated inside the particles by high-frequency magnetic field. Surface of the whole system is covered by several nanometers thin silica layer that provides rigidity and possibility of modification by specific receptors (targeting). Utilizing our system, we were able to remotely control a biochemical reaction between enzyme laccase and its substrate ABTS. The substrate was loaded into thermo-sensitive liposomes. Liposomes were prepared by hydration method followed by extrusion through polycarbonate membrane with pore-size of 100 nm. Magnetic nanoparticles were prepared by co-precipitation of FeCl2 and FeCl3. Liposomes, magnetite nanoparticles and the enzyme were dispersed in sodium alginate and the mixture was dripped into CaCl2 solution forming the gel particles. Concentration of oxidized form of ABTS in solution was detected spectroscopically at 420 nm. The influcence of iron oxide nanoparticle concentration, enzyme concentration, and hydrogel density on the kinetics of coupled reaction-diffusion processes from the composite particles was investigated.
- Many scientists deal with a problem of targeted delivery of drugs nowadays. Some of these substances are not very stable, so their synthesis ?in situ? is needed. Control of reaction and release of products requires complex system, using more chemical species and compartmentalization. Our particle is generally a small alginate gel droplet embedding internal compartments and other components. Liposomes play a role of the internal compartments, because permeability of their membrane could be greatly modified by temperature. Alginate beads also contain magnetite nanoparticles so heat can be generated inside the particles by high-frequency magnetic field. Surface of the whole system is covered by several nanometers thin silica layer that provides rigidity and possibility of modification by specific receptors (targeting). Utilizing our system, we were able to remotely control a biochemical reaction between enzyme laccase and its substrate ABTS. The substrate was loaded into thermo-sensitive liposomes. Liposomes were prepared by hydration method followed by extrusion through polycarbonate membrane with pore-size of 100 nm. Magnetic nanoparticles were prepared by co-precipitation of FeCl2 and FeCl3. Liposomes, magnetite nanoparticles and the enzyme were dispersed in sodium alginate and the mixture was dripped into CaCl2 solution forming the gel particles. Concentration of oxidized form of ABTS in solution was detected spectroscopically at 420 nm. The influcence of iron oxide nanoparticle concentration, enzyme concentration, and hydrogel density on the kinetics of coupled reaction-diffusion processes from the composite particles was investigated. (en)
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| Title
| - Remote control of reaction and diffusion processes inside microparticles
- Remote control of reaction and diffusion processes inside microparticles (en)
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| skos:prefLabel
| - Remote control of reaction and diffusion processes inside microparticles
- Remote control of reaction and diffusion processes inside microparticles (en)
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| skos:notation
| - RIV/60461373:22340/13:43895561!RIV14-MSM-22340___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/13:43895561
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - diffusion; targeting; liposome; remote control (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
| |
| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Proceedings of the 40th International Conference of Slovak Society of Chemical Engineering
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Haufová, Petra
- Štěpánek, František
- Hanuš, Jaroslav
- Ullrich, Martin
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| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
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| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Slovak Society of Chemical Engineering
|
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
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