About: Combined UV/vis and micro-tomography investigation of acetaminophen dissolution from granules

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The X-ray micro-tomography (micro-CT) technique has been used to visualize the microstructure of granules produced by high shear wet granulation and the dynamic evolution of porosity during granule dissolution. Using acetaminophen (paracetamol) as the active pharmaceutical ingredient (API) and microcrystalline cellulose (Avicel PH-200) as an excipient, the porosity of the granules was systematically influenced by the granulation process parameters (binder/solids ratio, impeller speed and wet massing time). An increase of granule porosity from 7% to 10% and 18% lead to a decrease of the dissolution time t90 from 435 min to 98 min and 37 min, respectively. The combination of time-resolved micro-CT imaging with UV/vis detection of the quantity dissolved made it possible to evaluate the effective diffusion coefficient of the API through the granule structure, and thus establish a quantitative structure?property relationship for dissolution. A power-law dependence of the effective diffusivity on porosity (Archie's law) was found to hold. The X-ray micro-tomography (micro-CT) technique has been used to visualize the microstructure of granules produced by high shear wet granulation and the dynamic evolution of porosity during granule dissolution. Using acetaminophen (paracetamol) as the active pharmaceutical ingredient (API) and microcrystalline cellulose (Avicel PH-200) as an excipient, the porosity of the granules was systematically influenced by the granulation process parameters (binder/solids ratio, impeller speed and wet massing time). An increase of granule porosity from 7% to 10% and 18% lead to a decrease of the dissolution time t90 from 435 min to 98 min and 37 min, respectively. The combination of time-resolved micro-CT imaging with UV/vis detection of the quantity dissolved made it possible to evaluate the effective diffusion coefficient of the API through the granule structure, and thus establish a quantitative structure?property relationship for dissolution. A power-law dependence of the effective diffusivity on porosity (Archie's law) was found to hold. (en)
Title	Combined UV/vis and micro-tomography investigation of acetaminophen dissolution from granules Combined UV/vis and micro-tomography investigation of acetaminophen dissolution from granules (en)
skos:prefLabel	Combined UV/vis and micro-tomography investigation of acetaminophen dissolution from granules Combined UV/vis and micro-tomography investigation of acetaminophen dissolution from granules (en)
skos:notation	RIV/60461373:22340/13:43895361!RIV14-MSM-22340___
http://linked.open...avai/predkladatel	Fakulta chemicko-inženýrská
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(LH12115), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štěpánek, František Tokárová, Viola Kašpar, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	65986
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/13:43895361
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Diffusion; Microstructure; Micro-CT; Porosity; Dissolution; Granulation (en)
http://linked.open.../riv/klicoveSlovo	Micro-CT Granulation Diffusion Microstructure Porosity Dissolution
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[663CC0692C90]
http://linked.open...i/riv/nazevZdroje	International Journal Pharm.
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Multi-scale analysis and design of granulation processes
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	458
http://linked.open...iv/tvurceVysledku	Tokárová, Viola Štěpánek, František Kašpar, Ondřej Ramachandran, Rohit Oka, Sarang Sowrirajan, Koushik
http://linked.open...ain/vavai/riv/wos	000327493700004
issn	0378-5173
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijpharm.2013.10.032
http://localhost/t...ganizacniJednotka	22340

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