About: Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer     Goto   Sponge   NotDistinct   Permalink

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Description
  • Objectives: The receptor for advanced glycation end-products (RAGE) takes part in the pathogenesis ofmany diseases, including diabetes mellitus and cancer. AGE-precursors are detoxified by glyoxalase (GLO).sRAGE, soluble RAGE, is an inhibitor of pathological effects mediated via RAGE. The aim was to study sRAGE and polymorphisms of RAGE (AGER) and GLO genes in patients with pancreas cancer (PC). Design and Methods: The studied group consisted of 51 patients with PC (34 with impaired glucose tolerance?IGT, 17without IGT), 34 type 2DMand 154 controls. For genetic analysis, the number of patients was increased to 170. Serum sRAGE was measured by ELISA and all polymorphisms (RAGE -429T/C, -374T/A, 2184A/G, Gly82Ser and GLO A419C) were determined by PCR-RFLP and confirmed by sequencing. Results: Soluble RAGE is decreased in patientswith PC compared to atients with DM and controls (975?532 vs. 1416?868 vs. 1723?643 pg/mL, p< 0.001). Patients with PC and IGT have lower sRAGE levels compared to pati
  • Objectives: The receptor for advanced glycation end-products (RAGE) takes part in the pathogenesis ofmany diseases, including diabetes mellitus and cancer. AGE-precursors are detoxified by glyoxalase (GLO).sRAGE, soluble RAGE, is an inhibitor of pathological effects mediated via RAGE. The aim was to study sRAGE and polymorphisms of RAGE (AGER) and GLO genes in patients with pancreas cancer (PC). Design and Methods: The studied group consisted of 51 patients with PC (34 with impaired glucose tolerance?IGT, 17without IGT), 34 type 2DMand 154 controls. For genetic analysis, the number of patients was increased to 170. Serum sRAGE was measured by ELISA and all polymorphisms (RAGE -429T/C, -374T/A, 2184A/G, Gly82Ser and GLO A419C) were determined by PCR-RFLP and confirmed by sequencing. Results: Soluble RAGE is decreased in patientswith PC compared to atients with DM and controls (975?532 vs. 1416?868 vs. 1723?643 pg/mL, p< 0.001). Patients with PC and IGT have lower sRAGE levels compared to pati (en)
Title
  • Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer
  • Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer (en)
skos:prefLabel
  • Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer
  • Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer (en)
skos:notation
  • RIV/60461373:22340/10:00023479!RIV11-MSM-22340___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NR9528), S
http://linked.open...iv/cisloPeriodika
  • 10-11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 288523
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22340/10:00023479
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cancer; Diabetes mellitus; Glyoxalase; Pancreas; Polymorphism; RAGE; Receptor for advanced glycation end products; Soluble receptor for advanced glycation end products sRAGE (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E4D5A0431D85]
http://linked.open...i/riv/nazevZdroje
  • Clinical Biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 43
http://linked.open...iv/tvurceVysledku
  • Mestek, Oto
  • Kalousová, M.
  • Zima, T.
  • Jáchymová, M.
  • Krechler, T.
  • Žák, A.
http://linked.open...ain/vavai/riv/wos
  • 000279133100015
issn
  • 0009-9120
number of pages
http://localhost/t...ganizacniJednotka
  • 22340
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