About: Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The new diastereomeric complexes of two oligo-N-methylpyrrole peptides, linked by a methano[1,5]-diazocin scaffold with DNA, were prepd. The specificity of the binding modes of (4S,9S)- and (4R,9R)-bis-distamycins deriv. with ct-DNA explains the obsd. optical activity of the racemic mixt. of distamycin if DNA is present. The bis-distamycin deriv. possesses a clear sequence selectivity for A-T rich sequences of DNA, although a nonspecific binding mode with low affinity was also seen for G-C rich sequences. The reversibility of ECD spectra at 5° after heating to 90° was established. The new diastereomeric complexes of two oligo-N-methylpyrrole peptides, linked by a methano[1,5]-diazocin scaffold with DNA, were prepd. The specificity of the binding modes of (4S,9S)- and (4R,9R)-bis-distamycins deriv. with ct-DNA explains the obsd. optical activity of the racemic mixt. of distamycin if DNA is present. The bis-distamycin deriv. possesses a clear sequence selectivity for A-T rich sequences of DNA, although a nonspecific binding mode with low affinity was also seen for G-C rich sequences. The reversibility of ECD spectra at 5° after heating to 90° was established. (en) Byly připraveny komplexy dvou oligo-N-methylpyrrolových peptidů spojených methano[1,5]-diazocinem s DNA. Byla pozorována optická aktivita racemické směsi distamycinu v přítomnosti DNA. (cs)
Title	Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study (en) Interakce chirálního bis-distamycinu s DNA: Studie elektronickym cirkulárním dichroismem (cs)
skos:prefLabel	Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study (en) Interakce chirálního bis-distamycinu s DNA: Studie elektronickym cirkulárním dichroismem (cs)
skos:notation	RIV/60461373:22340/06:00016727!RIV07-MSM-22340___
http://linked.open.../vavai/riv/strany	1049-1055
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6046137307)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Valík, Martin Palivec, Lukáš Král, Vladimír Urbanová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	479996
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/06:00016727
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trogers base; duplex DNA; analogs; recognition; complexes; ligands (en)
http://linked.open.../riv/klicoveSlovo	analogs duplex DNA complexes ligands recognition Trogers base
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[37A1C0673019]
http://linked.open...i/riv/nazevZdroje	Tetrahedron Asymmetry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Král, Vladimír Urbanová, Marie Valík, Martin Palivec, Lukáš
http://linked.open...n/vavai/riv/zamer	Physico-chemical methods of analysis and characterization of chemical systems and biosystems
issn	0957-4166
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22340
is http://linked.open...avai/riv/vysledek of	Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study

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