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| Description
| - This paper summarizes results achieved in labelling texaphyrin with radionuclides (e.g. with 177Lu) and characterization of the metal-texaphyrin complexes. Thin layer chromatography (TLC) method was used for the quality control of the 177Lu-labeled texaphyrin. Thermal analysis, mass spectroscopy (MS) and Fourier transform infrared spectroscopy (FT-IR) were used for the characterization of the Ca-texaphyrin, Lu-texaphyrin and Y-texaphyrin. The chemical and physical properties depend on the metal centrally placed into the cavity of the texaphyrin molecule. The labeling yield of the 177Lu-texaphyrin by the neutron irradiated Lu-Tex complex in the LVR-15 reactor was determined to be 40 %. The TLC technique is suitable for the separation of the 177Lu-Tex complex from the radionuclide 177Lu. The fact that texaphyrin exhibits a hight affinity of bonding to cancer cells is of great advantage as no antibody has to be applied.
- This paper summarizes results achieved in labelling texaphyrin with radionuclides (e.g. with 177Lu) and characterization of the metal-texaphyrin complexes. Thin layer chromatography (TLC) method was used for the quality control of the 177Lu-labeled texaphyrin. Thermal analysis, mass spectroscopy (MS) and Fourier transform infrared spectroscopy (FT-IR) were used for the characterization of the Ca-texaphyrin, Lu-texaphyrin and Y-texaphyrin. The chemical and physical properties depend on the metal centrally placed into the cavity of the texaphyrin molecule. The labeling yield of the 177Lu-texaphyrin by the neutron irradiated Lu-Tex complex in the LVR-15 reactor was determined to be 40 %. The TLC technique is suitable for the separation of the 177Lu-Tex complex from the radionuclide 177Lu. The fact that texaphyrin exhibits a hight affinity of bonding to cancer cells is of great advantage as no antibody has to be applied. (en)
- Tento článek shrnuje výsledky dosažené ve značení texafyrinu radionuklidy (např. s 177Lu) a charakterizaci komplexů kov-texafyrin. Metoda tenkovrstvé chromatografie (TLC) byla aplikována pro kontrolu kvality značení texafyrinu radionuklidem 177Lu. Termická analýza, hmotnostní spektroskopie (MS) a infračervená spektroskopie s Fourierovou transformací (FT-IR) byly použity pro charakterizaci Ca-texafyrin, Lu-texafyrin a Y-texafyrin. Chemické a fyzikální vlastnosti závisejí na centrálním kovu umístěném v kavitě texafyrinu. Ozářením komplexu Lu-Tex tokem neutronů v reaktoru LVR-15 byl stanoven výtěžek značení 40 %. Pro separaci komplexu 177Lu-Tex od radionuklidu 177Lu je vhodná TLC metoda. Skutečnost, že texafyrin vykazuje vysokou afinitu vázání na nádorové buňky je velkou výhodou, neboť není nezbytné využití protilátky. (cs)
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| Title
| - Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes
- Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes (en)
- Charakterizace komplexů kov-texafyrin a příprava komplexů radionuklid-texafyrin (cs)
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| skos:prefLabel
| - Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes
- Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes (en)
- Charakterizace komplexů kov-texafyrin a příprava komplexů radionuklid-texafyrin (cs)
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| skos:notation
| - RIV/60461373:22340/06:00016650!RIV07-MSM-22340___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/06:00016650
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - texaphyrin; radionuclides; labelling yield; metal-texaphyrin complexes; characterization and quality control (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Czechoslovak Journal of Physics
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Král, Vladimír
- Křížová, Věra
- Reková, Marie
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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