About: Analysis of reaction-transport phenomena in a Microfluidic System for Detection of IgG

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Studován byl prostorově 2D matematický model mikrofluidního biosenzoru pro imunoanalytické určení koncentrace lidského IgG pomocí Proteinu A imobilizovaného na vnitřních stěnách mikrokanálků. Analyzována byla zejména inkubační fáze imunoanalýzy, kdy dochází k formování imobilního komplexu IgG-Protein A. Bylo zjištěno, že povrchové heterogenity mohou mít za následek tvorbu složitých rychlostích políz v zóně tvorby komplexu. Tyto heterogenity však zpravidla způsobují pokles odporu proti přestupu hmoty. Vložené elektrické pole vhodné orientace může snížit potřebnou dobu inkubace pod 600s u kanálku s char. rozměrem 100 mikrometrů a zvolenou reakční kinetikou. (cs) A spatially two-dimensional mathematical model of micro-fluidic biosensor for immunological determination of human immunoglobulin G (IgG) with the use of Protein A (PA) immobilized on the internal walls of a micro-channel is presented. Incubation phase (formation of the immobile PA-IgG complex) of the immunoassay has been studied. It was found that the surface heterogeneities could form complex velocity fields at the location of the adsorption zone: either an intensive flow at the micro-channel walls or the nozzle-like flow. Generally, the local acceleration of the flow causes the decrease of the mass-transfer resistance. Further, imposed electric field of a proper orientation was able to shorten the incubation phase to 600 s, assuming the micro-channel device with the diameter of 100 mum and the chosen reaction kinetics. A spatially two-dimensional mathematical model of micro-fluidic biosensor for immunological determination of human immunoglobulin G (IgG) with the use of Protein A (PA) immobilized on the internal walls of a micro-channel is presented. Incubation phase (formation of the immobile PA-IgG complex) of the immunoassay has been studied. It was found that the surface heterogeneities could form complex velocity fields at the location of the adsorption zone: either an intensive flow at the micro-channel walls or the nozzle-like flow. Generally, the local acceleration of the flow causes the decrease of the mass-transfer resistance. Further, imposed electric field of a proper orientation was able to shorten the incubation phase to 600 s, assuming the micro-channel device with the diameter of 100 mum and the chosen reaction kinetics. (en)
Title	Analysis of reaction-transport phenomena in a Microfluidic System for Detection of IgG Analýza reakčně-transportních procesů v mikrofluidních systémech for detekci IgG (cs) Analysis of reaction-transport phenomena in a Microfluidic System for Detection of IgG (en)
skos:prefLabel	Analysis of reaction-transport phenomena in a Microfluidic System for Detection of IgG Analýza reakčně-transportních procesů v mikrofluidních systémech for detekci IgG (cs) Analysis of reaction-transport phenomena in a Microfluidic System for Detection of IgG (en)
skos:notation	RIV/60461373:22340/05:00014544!RIV06-GA0-22340___
http://linked.open.../vavai/riv/strany	434-440
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP104/03/D006)
http://linked.open...iv/cisloPeriodika	6a
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Marek, Miloš Přibyl, Michal Šnita, Dalimil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	512095
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/05:00014544
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microchip; immunoassay (en)
http://linked.open.../riv/klicoveSlovo	microchip immunoassay
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[2BBA66946DFA]
http://linked.open...i/riv/nazevZdroje	Chemical Papers
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of microreactors for bioengineering application
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Šnita, Dalimil Přibyl, Michal Marek, Miloš Knápková, Veronika
issn	0366-6352
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	22340
is http://linked.open...avai/riv/vysledek of	Analysis of reaction-transport phenomena in a Microfluidic System for Detection of IgG

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