About: Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Novel analogues of Troger's base were prepared regioselectively from 4-amono-N-methylpyrrole carboxylates in good yield. Catalytic hydrogenation ofdibenzyl-4,9-methano-l,6-dimethyl-4,5.9.10-tetrahydro-1H,6H-dipyrrolo- [3,2/b:3',2'-fII1,5]diazocin- 2,7-dicarboxylate 2b led to 4,9-methano-1,6-dimethyl-4,5,9,10-1H,6H-dipyrrolo-[3,2-b:3',2'-f][1,5]diazocin-2,7-dicargoxylic acid 3 which was used for the preparation of Troger's base derivatives of natural antibiotics via an amide protocol. The novel heterocyclic Troger's bases were characterized by a variety of spectroscopic techniques and compound 2b by X-ray crystallography. Incorporation of guanidine as the terminal group in the N-methylpyrrole Troger's base skeleton opens the possibility for preparationof water soluble derivatives. Novel analogues of Troger's base were prepared regioselectively from 4-amono-N-methylpyrrole carboxylates in good yield. Catalytic hydrogenation ofdibenzyl-4,9-methano-l,6-dimethyl-4,5.9.10-tetrahydro-1H,6H-dipyrrolo- [3,2/b:3',2'-fII1,5]diazocin- 2,7-dicarboxylate 2b led to 4,9-methano-1,6-dimethyl-4,5,9,10-1H,6H-dipyrrolo-[3,2-b:3',2'-f][1,5]diazocin-2,7-dicargoxylic acid 3 which was used for the preparation of Troger's base derivatives of natural antibiotics via an amide protocol. The novel heterocyclic Troger's bases were characterized by a variety of spectroscopic techniques and compound 2b by X-ray crystallography. Incorporation of guanidine as the terminal group in the N-methylpyrrole Troger's base skeleton opens the possibility for preparationof water soluble derivatives. (en)
Title	Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units (en)
skos:prefLabel	Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units (en)
skos:notation	RIV/60461373:22340/03:00007617!RIV/2004/GA0/223404/N
http://linked.open.../vavai/riv/strany	2083-2086
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/02/1193), Z(MSM 223400008)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Valík, Martin Petříčková, Hana Vašek, Petr Král, Vladimír Dolenský, Bohumil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	618428
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/03:00007617
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Troger´ s base; N-methylpyrrole; regioselectivity; guanidine (en)
http://linked.open.../riv/klicoveSlovo	regioselectivity N-methylpyrrole Troger´ s base guanidine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0677723CD0FA]
http://linked.open...i/riv/nazevZdroje	Tetrahedron Letters
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	GASEOUS SIGNALING IN THE NERVOUS SYSTEM (The role of NO and CO in the model system)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Král, Vladimír Vašek, Petr Dolenský, Bohumil Valík, Martin Petříčková, Hana
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223400008
issn	0040-4039
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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