About: Discrete models of autocrine cell communication in epithelial layers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pattern formation in epithelial layers heavily relies on cell communication by secreted ligands. Whereas the experimentally observed signaling patterns can be visualized at single-cell resolution, a biophysical framework for their interpretation is currently lacking. To this end, we develop a family of discrete models of cell communication in epithelial layers. The models are based on the introduction of cell-to-cell coupling coefficients that characterize the spatial range of intercellular signaling bydiffusing ligands. We derive the coupling coefficients as functions of geometric, cellular, and molecular parameters of the ligand transport problem. Using these coupling coefficients, we analyze a nonlinear model of positive feedback between ligand rel ease and binding. In particular, we study criteria of existence of the patterns consisting of clusters of a few signaling cells, as well as the onset of signal propagation. We use our model to interpret recent experimental studies of the EGFR/Rhomboid/Sp Pattern formation in epithelial layers heavily relies on cell communication by secreted ligands. Whereas the experimentally observed signaling patterns can be visualized at single-cell resolution, a biophysical framework for their interpretation is currently lacking. To this end, we develop a family of discrete models of cell communication in epithelial layers. The models are based on the introduction of cell-to-cell coupling coefficients that characterize the spatial range of intercellular signaling bydiffusing ligands. We derive the coupling coefficients as functions of geometric, cellular, and molecular parameters of the ligand transport problem. Using these coupling coefficients, we analyze a nonlinear model of positive feedback between ligand rel ease and binding. In particular, we study criteria of existence of the patterns consisting of clusters of a few signaling cells, as well as the onset of signal propagation. We use our model to interpret recent experimental studies of the EGFR/Rhomboid/Sp (en)
Title	Discrete models of autocrine cell communication in epithelial layers Discrete models of autocrine cell communication in epithelial layers (en)
skos:prefLabel	Discrete models of autocrine cell communication in epithelial layers Discrete models of autocrine cell communication in epithelial layers (en)
skos:notation	RIV/60461373:22340/03:00007557!RIV/2004/MSM/223404/N
http://linked.open.../vavai/riv/strany	3624-3635
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 223400007)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Přibyl, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	604046
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/03:00007557
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PROTEIN-KINASE CASCADE; GROWTH-FACTOR RECEPTOR; EGF RECEPTOR; DROSOPHILA-OOGENESIS; PATTERN-FORMATION; SIGNALING PATHWAYS; LATERAL INHIBITION; FACTOR-ALPHA; ACTIVATION; NETWORKS (en)
http://linked.open.../riv/klicoveSlovo	ACTIVATION NETWORKS DROSOPHILA-OOGENESIS EGF RECEPTOR FACTOR-ALPHA LATERAL INHIBITION PATTERN-FORMATION PROTEIN-KINASE CASCADE GROWTH-FACTOR RECEPTOR SIGNALING PATHWAYS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[27472A1C7889]
http://linked.open...i/riv/nazevZdroje	BIOPHYSICAL JOURNAL
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Přibyl, Michal Schvartsman, Stanislav Muratov, Cyrill
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223400007
issn	0006-3495
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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