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Description
| - Radioactive labelling guanidine-bearing tetraphenylporphyrin and Dy-texaphirin with selected radionuclides (166Ho and 90Y) is described. A basic characterisation of studied porphyrin and texaphyrin, including their behaviour in a wide range of pH values and data on holmium and yttrium complexation with these compounds was probed using UV-VIS absorption spectrometry. The labelling yield of these macrocyclic molecules depends on the pH of the reaction mixture, metal:ligand ratio and time of incubation. Optimal reaction conditions for formation of porphyrin and texaphyrin radioactive complexes were determined by thin layer chromatography with the detection of B- activity. The ability of porphyrin derivatives to bind anions was examined as well. Our eyperiments were focused on perrhenate ion (ReO4-) because radiopharmaceuticals labelled with isotopes 186Re and 188Re play an important role in therapy of numerous tumour diseases. The possibility of applying ReO4- anion directly for labelling purposes, witho
- Radioactive labelling guanidine-bearing tetraphenylporphyrin and Dy-texaphirin with selected radionuclides (166Ho and 90Y) is described. A basic characterisation of studied porphyrin and texaphyrin, including their behaviour in a wide range of pH values and data on holmium and yttrium complexation with these compounds was probed using UV-VIS absorption spectrometry. The labelling yield of these macrocyclic molecules depends on the pH of the reaction mixture, metal:ligand ratio and time of incubation. Optimal reaction conditions for formation of porphyrin and texaphyrin radioactive complexes were determined by thin layer chromatography with the detection of B- activity. The ability of porphyrin derivatives to bind anions was examined as well. Our eyperiments were focused on perrhenate ion (ReO4-) because radiopharmaceuticals labelled with isotopes 186Re and 188Re play an important role in therapy of numerous tumour diseases. The possibility of applying ReO4- anion directly for labelling purposes, witho (en)
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Title
| - Radioactively labelled porphyrin derivatives
- Radioactively labelled porphyrin derivatives (en)
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skos:prefLabel
| - Radioactively labelled porphyrin derivatives
- Radioactively labelled porphyrin derivatives (en)
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skos:notation
| - RIV/60461373:22340/03:00007460!RIV/2004/MSM/223404/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/03:00007460
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Holmium; Yttrium; Rhenium; Porphyrin; UV-VIS Spektrometry; Thin layer Chormatography (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Czechoslovak Journal of Physics
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Král, Vladimír
- Křížová, Věra
- Konířová, Radka
- Ernestová, Milena
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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