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rdf:type
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Description
| - The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M).
- The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M). (en)
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Title
| - Amides derived from heteroaromatic amines and selected steryl hemiesters
- Amides derived from heteroaromatic amines and selected steryl hemiesters (en)
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skos:prefLabel
| - Amides derived from heteroaromatic amines and selected steryl hemiesters
- Amides derived from heteroaromatic amines and selected steryl hemiesters (en)
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skos:notation
| - RIV/60461373:22330/13:43895382!RIV14-GA0-22330___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(ED0007/01/01), P(GAP503/11/0616), Z(MSM6046137305)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22330/13:43895382
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Cytotoxic activity; Amide; Lanosterol; Cholesterol; Heteroaromatic amine (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Havlíček, Libor
- Šaman, David
- Drašar, Pavel
- Rárová, Lucie
- Bildziukevich, Uladzimir
- Wimmer, Zdenek
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.steroids.2013.10.003
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http://localhost/t...ganizacniJednotka
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