About: Biological effect of beta-glucans on the molecular level

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	For decades beneficial biological effects of beta-glucans are known, but the principles of them have come to know only relatively recently. The main effect of beta-glucans, enhanced potential of the innate immune system, is related to their recognition by competent immunocytes. Recognition of beta-glucan is mediated through several transmembrane receptors: dectin-1, CR3, TLR2, TLR4, lactosylceramide and scavenger receptors, located on the surface of the white blood cells (macrophages, neutrophils, dendritic cells, natural killer cells, etc.). Binding of beta-glucan or its fragments to some of these receptors triggers a series of complicated signaling and reaction pathways, where cytokines, chemokines, enzymes and also certain genes play the irreplaceable role. In spite of the intensive research there are steps not yet rigorously described, but a general overview is progressively updated. As a result of these triggered responses, phagocytosis and intracellular oxidative burst take place, together with extracellular signaling activating other cells of the innate immune system. The summary of these cascade processes represents the very kernel of the above mentioned beta-glucans effects. For decades beneficial biological effects of beta-glucans are known, but the principles of them have come to know only relatively recently. The main effect of beta-glucans, enhanced potential of the innate immune system, is related to their recognition by competent immunocytes. Recognition of beta-glucan is mediated through several transmembrane receptors: dectin-1, CR3, TLR2, TLR4, lactosylceramide and scavenger receptors, located on the surface of the white blood cells (macrophages, neutrophils, dendritic cells, natural killer cells, etc.). Binding of beta-glucan or its fragments to some of these receptors triggers a series of complicated signaling and reaction pathways, where cytokines, chemokines, enzymes and also certain genes play the irreplaceable role. In spite of the intensive research there are steps not yet rigorously described, but a general overview is progressively updated. As a result of these triggered responses, phagocytosis and intracellular oxidative burst take place, together with extracellular signaling activating other cells of the innate immune system. The summary of these cascade processes represents the very kernel of the above mentioned beta-glucans effects. (en)
Title	Biological effect of beta-glucans on the molecular level Biological effect of beta-glucans on the molecular level (en)
skos:prefLabel	Biological effect of beta-glucans on the molecular level Biological effect of beta-glucans on the molecular level (en)
skos:notation	RIV/60461373:22330/11:43893114!RIV12-MSM-22330___
http://linked.open...avai/predkladatel	Fakulta potravinářské a biochemické technologie
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/09/1133), Z(MSM6046137305)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Čopíková, Jana Synytsya, Andriy
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	188318
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/11:43893114
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	beta-glucans, biological effect (en)
http://linked.open.../riv/klicoveSlovo	beta-glucans biological effect
http://linked.open...ontrolniKodProRIV	[73495270DF5F]
http://linked.open...v/mistoKonaniAkce	Praha
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Proceedings of the 7th International Conference on Polysaccharides - Glycoscience
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Properties of fungal polysaccharidic materials with physiological effects
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Novák, Miroslav Synytsya, Andriy Čopíková, Jana
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2011-11-02 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Česká společnost chemická
https://schema.org/isbn	978-80-86238-90-6
http://localhost/t...ganizacniJednotka	22330
is http://linked.open...avai/riv/vysledek of	Biological effect of beta-glucans on the molecular level Biological effect of beta-glucans on the molecular level

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