About: Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored. Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored. (en)
Title	Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives (en)
skos:prefLabel	Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives (en)
skos:notation	RIV/60461373:22330/11:43891709!RIV12-MSM-22330___
http://linked.open...avai/predkladatel	Fakulta potravinářské a biochemické technologie
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Füzik, Tibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	231384
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/11:43891709
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HL-60 cells; Cytotoxic activity; Reactive oxygen species; Spin trapping technique; EPR spectroscopy; Cathodic reduction; FT-IR; UV/vis spectroscopy; 4-Oxoquinolines (quinolones) (en)
http://linked.open.../riv/klicoveSlovo	Reactive oxygen species 4-Oxoquinolines (quinolones) Cathodic reduction HL-60 cells Spin trapping technique UV/vis spectroscopy EPR spectroscopy FT-IR Cytotoxic activity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[7726CB1619B8]
http://linked.open...i/riv/nazevZdroje	Journal of Photochemistry and Photobiology A: Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	224
http://linked.open...iv/tvurceVysledku	Barbierikova, Zuzana Bella, Maros Brezova, Vlasta Dvoranova, Dana Füzik, Tibor Jantova, Sona Lietava, Jozef Milata, Viktor Stasko, Andrej
http://linked.open...ain/vavai/riv/wos	000297189600017
issn	1010-6030
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	22330
is http://linked.open...avai/riv/vysledek of	Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives

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