About: Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics

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About: Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Článek popisuje vývoj a aplikaci imunoanalytické metody (cs) New combined radioimmunoassay for determination of 17-hydroxypregnenolone sulfate (17-PregS) involving the hydrolysis of analyte by methanolysis was developed. 17-PregS, in addition to being secreted by the adrenals, is also formed by peripheral sulfoconjugation of 17-hydroxypregnenolone (17-Preg) or directly by hydroxylation of pregnenolone sulfate with 17-hydroxylase/C17-20lyase. The measurement of 17-PregS can be used as a tool for detection of enzymatic deficiency particularly in pregnancy and for detection of congenital adrenal hyperplasia or gonadal dysfunction. The serum levels of 17-PregS, 17-Preg, dehydroepiandrosterone, dehydroepiandrosterone sulfate, pregnenolone and pregnenolone sulfate were measured in different age groups of human and in pregnant women respecting the age of gestation. The levels of 17-PregS are approximately three times higher than the levels of free 17-Preg in all subject groups. The levels of 17-PregS during pregnancy reached the local minimum in the 3rd mon New combined radioimmunoassay for determination of 17-hydroxypregnenolone sulfate (17-PregS) involving the hydrolysis of analyte by methanolysis was developed. 17-PregS, in addition to being secreted by the adrenals, is also formed by peripheral sulfoconjugation of 17-hydroxypregnenolone (17-Preg) or directly by hydroxylation of pregnenolone sulfate with 17-hydroxylase/C17-20lyase. The measurement of 17-PregS can be used as a tool for detection of enzymatic deficiency particularly in pregnancy and for detection of congenital adrenal hyperplasia or gonadal dysfunction. The serum levels of 17-PregS, 17-Preg, dehydroepiandrosterone, dehydroepiandrosterone sulfate, pregnenolone and pregnenolone sulfate were measured in different age groups of human and in pregnant women respecting the age of gestation. The levels of 17-PregS are approximately three times higher than the levels of free 17-Preg in all subject groups. The levels of 17-PregS during pregnancy reached the local minimum in the 3rd mon (en)
Title	Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics (en) Stanovení 17α-hydroxypregnenolon sulfátu a jeho aplikace v diagnostice (cs)
skos:prefLabel	Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics (en) Stanovení 17α-hydroxypregnenolon sulfátu a jeho aplikace v diagnostice (cs)
skos:notation	RIV/60461373:22330/07:00019019!RIV08-MSM-22330___
http://linked.open.../vavai/riv/strany	323-327
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Lapčík, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta potravinářské a biochemické technologie
http://linked.open...dnocenehoVysledku	416734
http://linked.open...ai/riv/idVysledku	RIV/60461373:22330/07:00019019
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Steroid; immunoassay; 17-hydroxy pregnenolone; RIA (en)
http://linked.open.../riv/klicoveSlovo	RIA Steroid immunoassay 17-hydroxy pregnenolone
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[1A0213708BC9]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Hill, Martin Lapčík, Oldřich Pařízek, A. Včeláková, Helena
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií
issn	0039-128X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	22330
is http://linked.open...avai/riv/vysledek of	Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics

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