About: Effect of Maize Starch Excipient Properties on Drug Release Rate

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S1877705812028391
Description	The aim of the work was to determine the influence of pregelatinized maize starch properties on the dissolution rate of caffeine. The intrinsic dissolution rate apparatus was used to investigate the process of drug dissolution. Dissolution profiles of caffeine mixed with 5 different maize starch samples, using caffeine: starch ratio (4:1), were measured. The dissolution profiles of all caffeine-starch mixtures are presented, as well as the results of the mathematical model, consisting of the equations for caffeine concentration change and for the starch layer change in time. The values of 3 parameters of the dissolution model were estimated using non-linear regression analysis. Caffeine effective diffusivity in swollen starch layer was found to be strongly related to the starch swelling capacity. The aim of the work was to determine the influence of pregelatinized maize starch properties on the dissolution rate of caffeine. The intrinsic dissolution rate apparatus was used to investigate the process of drug dissolution. Dissolution profiles of caffeine mixed with 5 different maize starch samples, using caffeine: starch ratio (4:1), were measured. The dissolution profiles of all caffeine-starch mixtures are presented, as well as the results of the mathematical model, consisting of the equations for caffeine concentration change and for the starch layer change in time. The values of 3 parameters of the dissolution model were estimated using non-linear regression analysis. Caffeine effective diffusivity in swollen starch layer was found to be strongly related to the starch swelling capacity. (en)
Title	Effect of Maize Starch Excipient Properties on Drug Release Rate Effect of Maize Starch Excipient Properties on Drug Release Rate (en)
skos:prefLabel	Effect of Maize Starch Excipient Properties on Drug Release Rate Effect of Maize Starch Excipient Properties on Drug Release Rate (en)
skos:notation	RIV/60461373:22310/12:43894823!RIV13-MSM-22310___
http://linked.open...avai/predkladatel	Fakulta chemické technologie
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0071), S
http://linked.open...iv/cisloPeriodika	September
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Zámostný, Petr Petrů, Jiří Majerová, Diana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	133136
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/12:43894823
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Maize starch; Caffeine; Diffusion; Release rate; Binder; Mathematical modeling; Intrinsic dissolution (en)
http://linked.open.../riv/klicoveSlovo	Mathematical modeling Caffeine Diffusion Binder Intrinsic dissolution Maize starch Release rate
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[48E8717B475F]
http://linked.open...i/riv/nazevZdroje	Procedia Engineering
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Unipetrol Centre of Research and Education
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Zámostný, Petr Majerová, Diana Petrů, Jiří
issn	1877-7058
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.proeng.2012.07.439
http://localhost/t...ganizacniJednotka	22310
is http://linked.open...avai/riv/vysledek of	Effect of Maize Starch Excipient Properties on Drug Release Rate

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