About: HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity

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About: HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	K[Pt(NH3)Cl3], a valuable precursor for the prepn. of platinum complexes with cytostatic activity, e.g. satraplatin, picoplatin, LA-12, and cycloplatam, is currently prepd. from cis-[Pt(NH3)2Cl2] or K2[PtCl4] and these are the usual impurities in the final product. A simple, selective, and sensitive HPLC-UV anal. method for the detn. of the purity of K[Pt(NH3)Cl3] and the quantification of the impurities was developed and validated. The platinum complexes present in the final product were sepd. on a strong base ion exchange column by the gradient elution with detection at 213 nm. Intra-assay precisions for the platinum complexes resp. to their ions ([PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2]) were between 0.1% and 2.0% (relative std. deviation); intermediate precisions were between 1.4% and 2.0% and accuracies were between 98.6% and 101.4%. Limits of detection of [PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2] were 6 mýg/mL-1, 13 mg/mL-1, and 5 mýg/mL-1 resp., limits of quantification of [PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2] were 51 mýg/mL-1, 55 mg/mL-1, and 20 mýg/mL-1 resp. K[Pt(NH3)Cl3], a valuable precursor for the prepn. of platinum complexes with cytostatic activity, e.g. satraplatin, picoplatin, LA-12, and cycloplatam, is currently prepd. from cis-[Pt(NH3)2Cl2] or K2[PtCl4] and these are the usual impurities in the final product. A simple, selective, and sensitive HPLC-UV anal. method for the detn. of the purity of K[Pt(NH3)Cl3] and the quantification of the impurities was developed and validated. The platinum complexes present in the final product were sepd. on a strong base ion exchange column by the gradient elution with detection at 213 nm. Intra-assay precisions for the platinum complexes resp. to their ions ([PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2]) were between 0.1% and 2.0% (relative std. deviation); intermediate precisions were between 1.4% and 2.0% and accuracies were between 98.6% and 101.4%. Limits of detection of [PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2] were 6 mýg/mL-1, 13 mg/mL-1, and 5 mýg/mL-1 resp., limits of quantification of [PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2] were 51 mýg/mL-1, 55 mg/mL-1, and 20 mýg/mL-1 resp. (en)
Title	HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity (en)
skos:prefLabel	HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity (en)
skos:notation	RIV/60461373:22310/11:43891933!RIV12-MPO-22310___
http://linked.open...avai/predkladatel	Fakulta chemické technologie
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2A-2TP1/049), P(GD203/08/H032)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kačer, Petr Holakovská, Jitka Červený, Libor Syslová, Kamila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	202847
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/11:43891933
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPLC-UV; cis-diamminedichloroplatinate(II) (en)
http://linked.open.../riv/klicoveSlovo	HPLC-UV cis-diamminedichloroplatinate(II)
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[AEC6B4029F42]
http://linked.open...i/riv/nazevZdroje	Anal.Lett.
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Advanced catalytic processes and materials *Research and development of platinum(II) complexes with the different aminoligands and their synthetic platinum intermediates.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Kačer, Petr Syslová, Kamila Hamtil, Roman Holakovská, Jitka Potucká, Lucie Červený, Libor
http://linked.open...ain/vavai/riv/wos	000294602900011
issn	0003-2719
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1080/00032719.2010.546027
http://localhost/t...ganizacniJednotka	22310
is http://linked.open...avai/riv/vysledek of	HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity

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