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Description
| - Toto studium rozšiřuje možnost použití lathyrogenů, beta-aminopropionitrilu a penicilaminu z denního nebo lokálního podávání na dlouhopůsobící činidlo. Toho bylo dosaženo převedením hydrofilního léku na lipofilní deriváty. Syntéza funkčních derivátů DPA spočívá v esterifikaci s methyl-, hexyl- a benzylalkoholem v přítomnosti thyonyl-chloridu. (cs)
- This study extends the use of two lathyrogens, beta-aminopropionitrile and penicillamine from daily systematic or local-topical administration to long time acting agents. This was achieved by converting the hydrophilic drugs into lipophilic derivatives. The synthesis of functional derivatives of DPA consisted in esterification with methyl-, hexyl- and benzyl alcohols in the presence of thionyl chloride.
- This study extends the use of two lathyrogens, beta-aminopropionitrile and penicillamine from daily systematic or local-topical administration to long time acting agents. This was achieved by converting the hydrophilic drugs into lipophilic derivatives. The synthesis of functional derivatives of DPA consisted in esterification with methyl-, hexyl- and benzyl alcohols in the presence of thionyl chloride. (en)
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Title
| - Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives
- Syntéza a studium dlouhopůsobící deriváty d-penicilaminu (cs)
- Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives (en)
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skos:prefLabel
| - Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives
- Syntéza a studium dlouhopůsobící deriváty d-penicilaminu (cs)
- Synthesis and Evaluation of Long-Acting d-Penicillamine Derivatives (en)
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skos:notation
| - RIV/60461373:22310/05:00013635!RIV06-MSM-22310___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22310/05:00013635
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Collagen as Scafold; Collagen Cross-Links; D-Penicillamine-Esters; Fibrosis, Lathyrogens; Wound Breaking Strength (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Connective Tissue Research
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Liška, František
- Šilhánková, Alexandra
- Kielar, F.
- Bregel, Klaus
- Chvapil, Miloš
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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