About: Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Design, syntéza a studium modelu fotolyasy (cs) Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2 are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition. Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2 are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition. (en)
Title	Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model (en) Design, syntéza a studium modelu fotolyasy (cs)
skos:prefLabel	Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model (en) Design, syntéza a studium modelu fotolyasy (cs)
skos:notation	RIV/60461373:22310/04:00011790!RIV/2005/MSM/223105/N
http://linked.open.../vavai/riv/strany	8183-8185
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 223100001)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Cibulka, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	559905
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/04:00011790
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Photolyase;enzyme models;flavin (en)
http://linked.open.../riv/klicoveSlovo	enzyme models flavin Photolyase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[44E8B7A0A7A5]
http://linked.open...i/riv/nazevZdroje	Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	69
http://linked.open...iv/tvurceVysledku	Cibulka, Radek König, B. Harrison, C. Saettel, N. Sax, M. Wiest, O.
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223100001
issn	0022-3263
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

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