About: Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring;

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About: Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring; Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A sensitive method for the determination of the N-methylcarbamoyl adduct at the N-terminal valine of globin, a new metabolic product of the industrial solvent N,N-dimethylformamide (DMF), has been developed and validated. The method includes conversion of the adduct by Edman degradation to 3-methyl-5-isopropylhydantoin (MVH). The limit of detection is 0.2 nmol MVH/g globin when a 100-mg sample is used. Within- and between-day precision is 4-10%. The method has been used to determine the background levels of the adduct in unexposed subjects. Further, toxicokinetic studies in volunteers laid the grounds for setting the reference value for biological monitoring of occupational exposure to DMF. A sensitive method for the determination of the N-methylcarbamoyl adduct at the N-terminal valine of globin, a new metabolic product of the industrial solvent N,N-dimethylformamide (DMF), has been developed and validated. The method includes conversion of the adduct by Edman degradation to 3-methyl-5-isopropylhydantoin (MVH). The limit of detection is 0.2 nmol MVH/g globin when a 100-mg sample is used. Within- and between-day precision is 4-10%. The method has been used to determine the background levels of the adduct in unexposed subjects. Further, toxicokinetic studies in volunteers laid the grounds for setting the reference value for biological monitoring of occupational exposure to DMF. (en)
Title	Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring; Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring; (en)
skos:prefLabel	Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring; Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring; (en)
skos:notation	RIV/60461373:22310/02:00006523!RIV/2004/MSM/223104/N
http://linked.open.../vavai/riv/strany	357-365
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 223100001)
http://linked.open...iv/cisloPeriodika	N
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Linhart, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	642746
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/02:00006523
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Determination of N-methylcarbamoylvaline; globin adducts; metabolism of N,N-dimethylformamide; biological monitoring; (en)
http://linked.open.../riv/klicoveSlovo	Determination of N-methylcarbamoylvaline globin adducts metabolism of N biological monitoring N-dimethylformamide
http://linked.open...odStatuVydavatele	BE - Belgické království
http://linked.open...ontrolniKodProRIV	[6698501E540E]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography B
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	778
http://linked.open...iv/tvurceVysledku	Linhart, Igor Mráz, Jaroslav
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223100001
issn	0021-9673
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

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