About: Caffeine alters oxidative homeostasis in the body of BALB/c mice

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About: Caffeine alters oxidative homeostasis in the body of BALB/c mice Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.elis.sk/download_file.php?product_id=4056&session_id=gc6otkblo722349n4fkp8heih0
Description	Caffeine is a metabolite from coffea genus and some other plants. It has disparate molecular targets in the body. Beside the major action based on antagonism on adenosine receptor, it is involved in other neurotransmission pathways as well. The complete mechanism of caffeine action remains unrevealed including link to oxidative homeostasis. For the reason, the current paper solves how caffeine influences oxidative homeostasis in BALB/c mouse model. Caffeine was given intramuscularly in doses 1 - 64 mg/kg and the animals were sacrificed in time intervals from 4 hours up to 3 days. In the experiment, significant increase of thiobarbituric acid reactive substances (TBARS) levels in the kidney and decrease in the brain indicates up and down regulation of oxidative burden. Ferric reducing antioxidant power (FRAP) level in the kidney appoint at release of low molecular weight antioxidants in the organ. The remaining organs including heart, muscles and liver were intact. In the same way, caspase 3 level was steady and no apoptotic processes were proved. Caffeine is a metabolite from coffea genus and some other plants. It has disparate molecular targets in the body. Beside the major action based on antagonism on adenosine receptor, it is involved in other neurotransmission pathways as well. The complete mechanism of caffeine action remains unrevealed including link to oxidative homeostasis. For the reason, the current paper solves how caffeine influences oxidative homeostasis in BALB/c mouse model. Caffeine was given intramuscularly in doses 1 - 64 mg/kg and the animals were sacrificed in time intervals from 4 hours up to 3 days. In the experiment, significant increase of thiobarbituric acid reactive substances (TBARS) levels in the kidney and decrease in the brain indicates up and down regulation of oxidative burden. Ferric reducing antioxidant power (FRAP) level in the kidney appoint at release of low molecular weight antioxidants in the organ. The remaining organs including heart, muscles and liver were intact. In the same way, caspase 3 level was steady and no apoptotic processes were proved. (en)
Title	Caffeine alters oxidative homeostasis in the body of BALB/c mice Caffeine alters oxidative homeostasis in the body of BALB/c mice (en)
skos:prefLabel	Caffeine alters oxidative homeostasis in the body of BALB/c mice Caffeine alters oxidative homeostasis in the body of BALB/c mice (en)
skos:notation	RIV/60162694:G44__/14:43875215!RIV15-MO0-G44_____
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	6046
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/14:43875215
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neurodegeneration; Alzheimer disease; adenosine receptor; antioxidant; oxidative stress; caffeine (en)
http://linked.open.../riv/klicoveSlovo	caffeine Alzheimer disease antioxidant oxidative stress adenosine receptor neurodegeneration
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[9644A1FDD974]
http://linked.open...i/riv/nazevZdroje	Bratislava Medical Journal-Bratislavske Lekarske Listy
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	115
http://linked.open...iv/tvurceVysledku	Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos	000346550800006
issn	0006-9248
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/BLL_2014_135
http://localhost/t...ganizacniJednotka	G44

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