About: Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity     Goto   Sponge   NotDistinct   Permalink

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Description
  • Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a %22cholinergic anti-inflammatory pathway%22 which raises questions about the role of these inhibitors in the immune system. This review covers research and discussion of the role of the inhibitors in modulating the immune response using as examples the commonly available drugs, donepezil, galantamine, huperzine, neostigmine and pyridostigmine. Major attention is given to the cholinergic anti-inflammatory pathway, a well-described link between the central nervous system and terminal effector cells in the immune system.
  • Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a %22cholinergic anti-inflammatory pathway%22 which raises questions about the role of these inhibitors in the immune system. This review covers research and discussion of the role of the inhibitors in modulating the immune response using as examples the commonly available drugs, donepezil, galantamine, huperzine, neostigmine and pyridostigmine. Major attention is given to the cholinergic anti-inflammatory pathway, a well-described link between the central nervous system and terminal effector cells in the immune system. (en)
Title
  • Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity
  • Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity (en)
skos:prefLabel
  • Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity
  • Inhibitors of acetylcholinesterase and butyrylcholinesterase meet immunity (en)
skos:notation
  • RIV/60162694:G44__/14:43875095!RIV15-MSM-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LH11023)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
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  • 21856
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/14:43875095
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • neuromodulation; neuroimmunity; Alzheimer disease; butyrylcholinesterase; acetylcholinesterase; cholinergic anti-inflammatory pathway (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [05B44C220632]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Molecular Sciences
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http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 15
http://linked.open...iv/tvurceVysledku
  • Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos
  • 000338639000036
issn
  • 1422-0067
number of pages
http://bibframe.org/vocab/doi
  • 10.3390/ijms15069809
http://localhost/t...ganizacniJednotka
  • G44
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